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Tinf2 TERF1 interacting nuclear factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290232, updated on 5-Mar-2024

Summary

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Official Symbol
Tinf2provided by RGD
Official Full Name
TERF1 interacting nuclear factor 2provided by RGD
Primary source
RGD:1359192
See related
Ensembl:ENSRNOG00000020189 AllianceGenome:RGD:1359192
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable telomeric DNA binding activity. Predicted to be involved in several processes, including negative regulation of nitrogen compound metabolic process; protein localization to chromosome, telomeric region; and telomere organization. Predicted to act upstream of or within negative regulation of telomere maintenance. Predicted to be located in chromosome, telomeric region; nuclear body; and perinucleolar chromocenter. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in Revesz syndrome and autosomal dominant dyskeratosis congenita 3. Orthologous to human TINF2 (TERF1 interacting nuclear factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 108.6), Spleen (RPKM 101.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33140611..33146930, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29170663..29178015, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34358697..34365085, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene guanosine monophosphate reductase 2 Neighboring gene transglutaminase 1 Neighboring gene Rab geranylgeranyltransferase subunit alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes. Walne AJ, et al. Blood, 2008 Nov 1. PMID 18669893, Free PMC Article
  2. Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. Kim SH, et al. J Cell Biol, 2008 May 5. PMID 18443218, Free PMC Article
  3. Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. Kaminker P, et al. J Cell Sci, 2005 Mar 15. PMID 15741234, Free PMC Article
  4. Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Chiang YJ, et al. Mol Cell Biol, 2004 Aug. PMID 15254230, Free PMC Article
  5. Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2. Kim SH, et al. Genomics, 2003 Apr. PMID 12676566

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94711

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere capping ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear telomere cap complex ISO
Inferred from Sequence Orthology
more info
  
located_in perinucleolar chromocenter ISO
Inferred from Sequence Orthology
more info
  
part_of shelterin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of shelterin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TERF1-interacting nuclear factor 2
Names
TERF1 (TRF1)-interacting nuclear factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006962.1 → NP_001006963.1  TERF1-interacting nuclear factor 2

    See identical proteins and their annotated locations for NP_001006963.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083766
    UniProtKB/TrEMBL
    A6KH37, F7F4I8, Q5XIB8
    Related
    ENSRNOP00000027362.5, ENSRNOT00000027362.6
    Conserved Domains (2) summary
    cd11741
    Location:226 → 321
    TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
    pfam14973
    Location:20 → 153
    TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33140611..33146930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251944.5 → XP_006252006.1  TERF1-interacting nuclear factor 2 isoform X5

    Conserved Domains (2) summary
    cd11741
    Location:226 → 321
    TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
    pfam14973
    Location:20 → 153
    TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

  2. XM_006251943.5 → XP_006252005.1  TERF1-interacting nuclear factor 2 isoform X4

    Conserved Domains (2) summary
    cd11741
    Location:226 → 321
    TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
    pfam14973
    Location:20 → 153
    TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

  3. XM_006251942.5 → XP_006252004.1  TERF1-interacting nuclear factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZKC5
    Related
    ENSRNOP00000077645.1
    Conserved Domains (2) summary
    cd11741
    Location:226 → 321
    TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
    pfam14973
    Location:20 → 153
    TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

  4. XM_039093130.2 → XP_038949058.1  TERF1-interacting nuclear factor 2 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:188 → 392
    PHA03247; large tegument protein UL36; Provisional
    cd11741
    Location:226 → 321
    TIN2_TBM; TRF-binding motif region of TRF-Interacting Nuclear factor 2
    pfam14973
    Location:20 → 153
    TINF2_N; TERF1-interacting nuclear factor 2 N-terminus

  5. XM_063274126.1 → XP_063130196.1  TERF1-interacting nuclear factor 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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