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Wapl WAPL cohesin release factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 290577, updated on 13-Apr-2024

Summary

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Official Symbol
Waplprovided by RGD
Official Full Name
WAPL cohesin release factorprovided by RGD
Primary source
RGD:1590924
See related
Ensembl:ENSRNOG00000052513 AllianceGenome:RGD:1590924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wapal; RGD1308960
Summary
Predicted to be involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of chromosome organization. Predicted to act upstream of or within several processes, including positive regulation of fibroblast proliferation; regulation of chromosome segregation; and response to toxic substance. Predicted to be located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nuclear lumen. Orthologous to human WAPL (WAPL cohesin release factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 407.2), Spleen (RPKM 367.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p15
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (10011741..10081472)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (10005520..10075270)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (11029325..11108867)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4, pseudogene 2 Neighboring gene opsin 4 Neighboring gene iron-sulfur cluster assembly 1, pseudogene 1 Neighboring gene cofilin 1, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Shintomi K, et al. Genes Dev, 2009 Sep 15. PMID 19696148, Free PMC Article
  2. A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis. Kuroda M, et al. FEBS Lett, 2005 Jan 3. PMID 15620708
  3. Wapl is an essential regulator of chromatin structure and chromosome segregation. Tedeschi A, et al. Nature, 2013 Sep 26. PMID 23975099, Free PMC Article
  4. Cohesin acetylation speeds the replication fork. Terret ME, et al. Nature, 2009 Nov 12. PMID 19907496, Free PMC Article
  5. Wapl controls the dynamic association of cohesin with chromatin. Kueng S, et al. Cell, 2006 Dec 1. PMID 17113138

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP-dependent protein-DNA unloader activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
wings apart-like protein homolog
Names
wings apart-like homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427279.1 → NP_001414208.1  wings apart-like protein homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    D4ADT3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    10011741..10081472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252726.5 → XP_006252788.2  wings apart-like protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZX5
    Related
    ENSRNOP00000083400.1
    Conserved Domains (1) summary
    pfam07814
    Location:595 → 955
    WAPL; Wings apart-like protein regulation of heterochromatin

  2. XM_006252725.5 → XP_006252787.2  wings apart-like protein homolog isoform X2

    Conserved Domains (1) summary
    pfam07814
    Location:640 → 1000
    WAPL; Wings apart-like protein regulation of heterochromatin

  3. XM_063275139.1 → XP_063131209.1  wings apart-like protein homolog isoform X4

  4. XM_006252724.5 → XP_006252786.2  wings apart-like protein homolog isoform X1

    UniProtKB/TrEMBL
    D4ADT3
    Related
    ENSRNOP00000070173.2
    Conserved Domains (1) summary
    pfam07814
    Location:646 → 1006
    WAPL; Wings apart-like protein regulation of heterochromatin
Nucleotide Protein Strain
Heading Accession and Version

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