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THYN1 thymocyte nuclear protein 1 [ Homo sapiens (human) ]

Gene ID: 29087, updated on 5-Mar-2024

Summary

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Official Symbol
THYN1provided by HGNC
Official Full Name
thymocyte nuclear protein 1provided by HGNC
Primary source
HGNC:HGNC:29560
See related
Ensembl:ENSG00000151500 MIM:613739; AllianceGenome:HGNC:29560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MY105; THY28; MDS012; HSPC144; THY28KD
Summary
This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 21.0), ovary (RPKM 20.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q25
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (134248282..134253352, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (134290127..134295197, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (134118176..134123246, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene non-SMC condensin II complex subunit D3 Neighboring gene zinc finger protein 628 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:134045931-134047130 Neighboring gene MPRA-validated peak1520 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4093 Neighboring gene MPRA-validated peak1521 silencer Neighboring gene MPRA-validated peak1522 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5770 Neighboring gene VPS26 retromer complex component B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5771 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4096 Neighboring gene acyl-CoA dehydrogenase family member 8 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:134142736-134143291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4097 Neighboring gene galactosidase beta 1 like 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:134180995-134181180 Neighboring gene ATPase H+/K+ transporting subunit beta pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification, expression, and purification of a unique stable domain from human HSPC144 protein. Song AX, et al. Protein Expr Purif, 2005 Jul. PMID 15939300
  2. Modulation of mThy28 nuclear protein expression during thymocyte development. Jiang X, et al. Tissue Cell, 2003 Dec. PMID 14580360
  3. Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells. Jiang XZ, et al. Apoptosis, 2003 Oct. PMID 14601557
  4. Molecular cloning and characterization of the mouse thymocyte protein gene. Miyaji H, et al. Gene, 2002 Sep 4. PMID 12384300
  5. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107411

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The 2.3A-resolution structure revealed only one 2-fold axis of rotational pseudosymmetry. A potential RNA-binding domain from human YTH-domain-containing protein 2 has the most similar 3-D fold to that of the DUF55 domain; it may be an RNA-related domain.
    Title: Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry.
  2. HSPC144 was expressed and purified, and a stable fragment (residues 44-225) was identified by limited proteolysis method.
    Title: Identification, expression, and purification of a unique stable domain from human HSPC144 protein.
  3. Studies of the mouse counterpart.
    Title: Molecular cloning and characterization of the mouse thymocyte protein gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12187

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
thymocyte nuclear protein 1
Names
thymocyte protein thy28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037304.2 → NP_001032381.1  thymocyte nuclear protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001032381.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Isoform 2 is also encoded by variant 2.
    Source sequence(s)
    BC006978, BU685681, BU934600
    Consensus CDS
    CCDS8497.1
    UniProtKB/Swiss-Prot
    Q9P016
    Conserved Domains (1) summary
    cl00728
    Location:57 → 160
    EVE; EVE domain

  2. NM_001037305.2 → NP_001032382.1  thymocyte nuclear protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001032382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 5 encode the same isoform (1).
    Source sequence(s)
    BC093074, BQ640137, BU685681
    Consensus CDS
    CCDS8496.1
    UniProtKB/Swiss-Prot
    Q567Q2, Q9H3L4, Q9HC20, Q9P016
    Related
    ENSP00000376373.3, ENST00000392594.7
    Conserved Domains (1) summary
    cd21133
    Location:55 → 219
    EVE; EVE domains are putative RNA-binding domains that belong to the PUA superfamily

  3. NM_014174.3 → NP_054893.1  thymocyte nuclear protein 1 isoform 1

    See identical proteins and their annotated locations for NP_054893.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Isoform 1 is also encoded by variants 3 and 5.
    Source sequence(s)
    AF161493, BQ959408
    Consensus CDS
    CCDS8496.1
    UniProtKB/Swiss-Prot
    Q567Q2, Q9H3L4, Q9HC20, Q9P016
    Related
    ENSP00000341657.3, ENST00000341541.8
    Conserved Domains (1) summary
    cd21133
    Location:55 → 219
    EVE; EVE domains are putative RNA-binding domains that belong to the PUA superfamily

  4. NM_199297.2 → NP_954994.1  thymocyte nuclear protein 1 isoform 2

    See identical proteins and their annotated locations for NP_954994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Isoform 2 is also encoded by variant 4.
    Source sequence(s)
    AF182413, BC006978, BU658940
    Consensus CDS
    CCDS8497.1
    UniProtKB/Swiss-Prot
    Q9P016
    Related
    ENSP00000341452.5, ENST00000352327.5
    Conserved Domains (1) summary
    cl00728
    Location:57 → 160
    EVE; EVE domain

  5. NM_199298.2 → NP_954995.1  thymocyte nuclear protein 1 isoform 1

    See identical proteins and their annotated locations for NP_954995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 5 encode the same isoform (1).
    Source sequence(s)
    AF161493, BU658940
    Consensus CDS
    CCDS8496.1
    UniProtKB/Swiss-Prot
    Q567Q2, Q9H3L4, Q9HC20, Q9P016
    Related
    ENSP00000376374.2, ENST00000392595.6
    Conserved Domains (1) summary
    cd21133
    Location:55 → 219
    EVE; EVE domains are putative RNA-binding domains that belong to the PUA superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    134248282..134253352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    134290127..134295197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P016.1 GenPept UniProtKB/Swiss-Prot:Q9P016

Gene LinkOut

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