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Fastkd3 FAST kinase domains 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290946, updated on 5-Mar-2024

Summary

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Official Symbol
Fastkd3provided by RGD
Official Full Name
FAST kinase domains 3provided by RGD
Primary source
RGD:1309729
See related
Ensembl:ENSRNOG00000027422 AllianceGenome:RGD:1309729
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309729
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing; mitochondrial cytochrome c oxidase assembly; and posttranscriptional regulation of gene expression. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human FASTKD3 (FAST kinase domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 59.6), Kidney (RPKM 56.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1p11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (36686727..36695376, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (34858342..34866988, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (37734400..37742932, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 2 Neighboring gene RNA, U6 small nuclear 783 Neighboring gene cilia and flagella associated protein 90 Neighboring gene uncharacterized LOC134482589 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression. Boehm E, et al. J Biol Chem, 2016 Dec 9. PMID 27789713, Free PMC Article
  2. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial mRNA stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitochondrial mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial mRNA stability ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FAST kinase domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082574.1 → NP_001076043.1  FAST kinase domain-containing protein 3, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001076043.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079475, CK359441
    UniProtKB/Swiss-Prot
    Q68FN9
    UniProtKB/TrEMBL
    A6JV27
    Related
    ENSRNOP00000029498.4, ENSRNOT00000034410.7
    Conserved Domains (3) summary
    smart00952
    Location:589 → 646
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:405 → 473
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:489 → 575
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    36686727..36695376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006227811.3 → XP_006227873.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006227873.1

    UniProtKB/Swiss-Prot
    Q68FN9
    UniProtKB/TrEMBL
    A6JV27
    Conserved Domains (3) summary
    smart00952
    Location:589 → 646
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:405 → 473
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:489 → 575
    FAST_2; FAST kinase-like protein, subdomain 2

  2. XM_006227809.4 → XP_006227871.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006227871.1

    UniProtKB/Swiss-Prot
    Q68FN9
    UniProtKB/TrEMBL
    A6JV27
    Conserved Domains (3) summary
    smart00952
    Location:589 → 646
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:405 → 473
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:489 → 575
    FAST_2; FAST kinase-like protein, subdomain 2

  3. XM_039102861.2 → XP_038958789.1  FAST kinase domain-containing protein 3, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6JV28
    Conserved Domains (2) summary
    smart00952
    Location:120 → 177
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam08368
    Location:18 → 106
    FAST_2; FAST kinase-like protein, subdomain 2

  4. XM_063282704.1 → XP_063138774.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

RNA

  1. XR_010063812.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FN9.2 GenPept UniProtKB/Swiss-Prot:Q68FN9

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