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Aopep aminopeptidase O [ Rattus norvegicus (Norway rat) ]

Gene ID: 290963, updated on 22-Aug-2021

Summary

Official Symbol
Aopepprovided by RGD
Official Full Name
aminopeptidase Oprovided by RGD
Primary source
RGD:1309592
See related
Ensembl:ENSRNOG00000017505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Apo; Npepo; RGD1309592
Expression
Biased expression in Lung (RPKM 178.3), Heart (RPKM 176.6) and 9 other tissues See more
Orthologs
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Genomic context

See Aopep in Genome Data Viewer
Location:
17p14
Exon count:
22
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (1811922..2127316, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (507389..825062)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene patched 1 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene FA complementation group C Neighboring gene microRNA 3074 Neighboring gene microRNA 24-1 Neighboring gene microRNA 27b Neighboring gene microRNA 23b Neighboring gene uncharacterized LOC102551048 Neighboring gene fructose-bisphosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
aminopeptidase O
Names
AP-O

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012346.2NP_001012346.2  aminopeptidase O

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000284

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    1811922..2127316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771432.3XP_008769654.1  aminopeptidase O isoform X2

    See identical proteins and their annotated locations for XP_008769654.1

    UniProtKB/TrEMBL
    F1LRV1
    Conserved Domains (2) summary
    pfam09127
    Location:679820
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:186633
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  2. XM_008771431.3XP_008769653.1  aminopeptidase O isoform X2

    See identical proteins and their annotated locations for XP_008769653.1

    UniProtKB/TrEMBL
    F1LRV1
    Related
    ENSRNOP00000023638.6
    Conserved Domains (2) summary
    pfam09127
    Location:679820
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:186633
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  3. XM_017600471.2XP_017455960.1  aminopeptidase O isoform X1

    Conserved Domains (2) summary
    pfam09127
    Location:743884
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:250697
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  4. XM_039095440.1XP_038951368.1  aminopeptidase O isoform X3

    Conserved Domains (2) summary
    pfam09127
    Location:691803
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:308622
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  5. XM_039095441.1XP_038951369.1  aminopeptidase O isoform X4

    Conserved Domains (2) summary
    pfam09127
    Location:674786
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:308605
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  6. XM_008771430.3XP_008769652.1  aminopeptidase O isoform X1

    See identical proteins and their annotated locations for XP_008769652.1

    Conserved Domains (2) summary
    pfam09127
    Location:743884
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:250697
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  7. XM_017600472.2XP_017455961.1  aminopeptidase O isoform X1

    Conserved Domains (2) summary
    pfam09127
    Location:743884
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:250697
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  8. XM_008771429.3XP_008769651.1  aminopeptidase O isoform X1

    See identical proteins and their annotated locations for XP_008769651.1

    Conserved Domains (2) summary
    pfam09127
    Location:743884
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:250697
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  9. XM_017600473.2XP_017455962.1  aminopeptidase O isoform X2

    UniProtKB/TrEMBL
    F1LRV1
    Conserved Domains (2) summary
    pfam09127
    Location:679820
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:186633
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  10. XM_039095444.1XP_038951372.1  aminopeptidase O isoform X7

    Conserved Domains (2) summary
    TIGR02411
    Location:44436
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    pfam09127
    Location:328440
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
  11. XM_039095442.1XP_038951370.1  aminopeptidase O isoform X5

    Conserved Domains (1) summary
    cl14813
    Location:308704
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  12. XM_039095443.1XP_038951371.1  aminopeptidase O isoform X6

    Conserved Domains (1) summary
    cl14813
    Location:308408
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RNA

  1. XR_005495243.1 RNA Sequence

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