U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Uimc1 ubiquitin interaction motif containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290997, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Uimc1provided by RGD
Official Full Name
ubiquitin interaction motif containing 1provided by RGD
Primary source
RGD:1307009
See related
Ensembl:ENSRNOG00000016891 AllianceGenome:RGD:1307009
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307009
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; histone binding activity; and retinoid X receptor binding activity. Predicted to be involved in several processes, including histone H2A K63-linked deubiquitination; mitotic G2 DNA damage checkpoint signaling; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nuclear body. Predicted to be part of BRCA1-A complex. Orthologous to human UIMC1 (ubiquitin interaction motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 119.0), Thymus (RPKM 118.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17p14
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9528923..9597967)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9523793..9592810)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10061915..10130921)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 4 Neighboring gene zinc finger protein 346 Neighboring gene hexokinase 3 Neighboring gene unc-5 netrin receptor A Neighboring gene uncharacterized LOC120097834

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks. Shao G, et al. Proc Natl Acad Sci U S A, 2009 Mar 3. PMID 19202061, Free PMC Article
  2. RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. Yan Z, et al. J Biol Chem, 2002 Aug 30. PMID 12080054
  3. CCDC98 targets BRCA1 to DNA damage sites. Liu Z, et al. Nat Struct Mol Biol, 2007 Aug. PMID 17643121
  4. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Kim H, et al. Science, 2007 May 25. PMID 17525342
  5. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Wang B, et al. Science, 2007 May 25. PMID 17525340, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-modified histone reader activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-modified histone reader activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
  
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
  
part_of BRCA1-A complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
BRCA1-A complex subunit RAP80
Names
receptor-associated protein 80
ubiquitin interaction motif-containing protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013884.1 → NP_001013906.1  BRCA1-A complex subunit RAP80

    See identical proteins and their annotated locations for NP_001013906.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087149
    UniProtKB/Swiss-Prot
    Q5PQK4
    UniProtKB/TrEMBL
    A0A8I6ALX5
    Related
    ENSRNOP00000022704.6, ENSRNOT00000022703.7
    Conserved Domains (2) summary
    pfam18282
    Location:72 → 128
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
    cd20912
    Location:272 → 330
    AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    9528923..9597967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276146.1 → XP_063132216.1  BRCA1-A complex subunit RAP80 isoform X2

    UniProtKB/Swiss-Prot
    Q5PQK4

  2. XM_039095471.2 → XP_038951399.1  BRCA1-A complex subunit RAP80 isoform X2

    UniProtKB/Swiss-Prot
    Q5PQK4
    UniProtKB/TrEMBL
    A0A8I6ALX5
    Conserved Domains (2) summary
    pfam18282
    Location:72 → 128
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
    cd20912
    Location:272 → 330
    AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains

  3. XM_063276145.1 → XP_063132215.1  BRCA1-A complex subunit RAP80 isoform X2

    UniProtKB/Swiss-Prot
    Q5PQK4

  4. XM_063276147.1 → XP_063132217.1  BRCA1-A complex subunit RAP80 isoform X4

  5. XM_039095470.2 → XP_038951398.1  BRCA1-A complex subunit RAP80 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K556, A0A8I6ALX5
    Related
    ENSRNOP00000073299.1
    Conserved Domains (2) summary
    pfam18282
    Location:96 → 152
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
    cd20912
    Location:296 → 354
    AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains

  6. XM_017600476.3 → XP_017455965.2  BRCA1-A complex subunit RAP80 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ALX5
    Conserved Domains (1) summary
    pfam18282
    Location:96 → 152
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

  7. XM_039095472.2 → XP_038951400.1  BRCA1-A complex subunit RAP80 isoform X2

    UniProtKB/Swiss-Prot
    Q5PQK4
    UniProtKB/TrEMBL
    A0A8I6ALX5
    Conserved Domains (2) summary
    pfam18282
    Location:72 → 128
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif
    cd20912
    Location:272 → 330
    AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains

RNA

  1. XR_010058818.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQK4.1 GenPept UniProtKB/Swiss-Prot:Q5PQK4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous