Serpinb6a serpin family B member 6A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpinb6aprovided by RGD
Official Full Name: serpin family B member 6Aprovided by RGD
Primary source: RGD:735108
See related: Ensembl:ENSRNOG00000017962 AllianceGenome:RGD:735108
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Serpinb6
Summary: Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Predicted to be part of serine protease inhibitor complex. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 398.9), Heart (RPKM 281.4) and 9 other tissues See more
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Genomic context

Location:: 17p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (31076811..31195035)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (30871468..30989703)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (32154747..32209598)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Serpinb6b (e-PCR), detects polymorphism
- UniSTS:525941

RH129867 (e-PCR)
- UniSTS:213155

Serpinb6 (e-PCR), detects polymorphism
- UniSTS:256987

Serpinb6c (e-PCR), detects polymorphism
- UniSTS:526835

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protease binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of serine protease inhibitor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serpin B6

Names: serine (or cysteine) peptidase inhibitor, clade B, member 6a; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; serpin family B member 6; serpin peptidase inhibitor, clade B (ovalbumin), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395026.1 → NP_001381955.1 serpin B6

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6ABJ3, A6J7I2, F7EUC3, Q6P9U0

Related

ENSRNOP00000090303.1, ENSRNOT00000118879.1

Conserved Domains (1) summary

cd19565
Location:1 → 379

serpinB6_CAP; serpin family B member 6, cytoplasmic antiproteinase
NM_001395027.1 → NP_001381956.1 serpin B6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6ABJ3, A6J7I2, F7EUC3, Q6P9U0

Conserved Domains (1) summary

cd19565
Location:1 → 379

serpinB6_CAP; serpin family B member 6, cytoplasmic antiproteinase
NM_199085.3 → NP_954516.1 serpin B6

See identical proteins and their annotated locations for NP_954516.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6ABJ3, A6J7I2, F7EUC3, Q6P9U0

Related

ENSRNOP00000024161.6, ENSRNOT00000024161.6

Conserved Domains (1) summary

cd19565
Location:1 → 379

serpinB6_CAP; serpin family B member 6, cytoplasmic antiproteinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

31076811..31195035

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095492.2 → XP_038951420.1 serpin B6 isoform X1

UniProtKB/TrEMBL

A0A8I6ABJ3, A6J7I2, F7EUC3, Q6P9U0

Conserved Domains (1) summary

cd19565
Location:1 → 379

serpinB6_CAP; serpin family B member 6, cytoplasmic antiproteinase
XM_006253871.4 → XP_006253933.1 serpin B6 isoform X2

UniProtKB/TrEMBL

A0A8I6A6H8, F7EUC3

Related

ENSRNOP00000089104.1

Conserved Domains (1) summary

cl00137
Location:25 → 400

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...