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Canx calnexin [ Rattus norvegicus (Norway rat) ]

Gene ID: 29144, updated on 22-Aug-2021

Summary

Official Symbol
Canxprovided by RGD
Official Full Name
calnexinprovided by RGD
Primary source
RGD:2266
See related
Ensembl:ENSRNOG00000003343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
calcium-binding protein that may serve to chaperone proteins from the ER to outer cellular membrane [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 1097.7), Liver (RPKM 895.6) and 9 other tissues See more
Orthologs
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Genomic context

See Canx in Genome Data Viewer
Location:
10q22
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34623865..34656866, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35800942..35833939, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095091 Neighboring gene leukotriene C4 synthase Neighboring gene mastermind-like transcriptional coactivator 1 Neighboring gene uncharacterized LOC120095092 Neighboring gene chibby family member 3 Neighboring gene heterogeneous nuclear ribonucleoprotein H1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables apolipoprotein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin-dependent endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum quality control compartment ISO
Inferred from Sequence Orthology
more info
 
NOT located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
located_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of presynaptic active zone membrane EXP
Inferred from Experiment
more info
PubMed 
located_in integral component of presynaptic active zone membrane EXP
Inferred from Experiment
more info
PubMed 
is_active_in integral component of presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondria-associated endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172008.2NP_742005.1  calnexin precursor

    See identical proteins and their annotated locations for NP_742005.1

    Status: VALIDATED

    Source sequence(s)
    CB586187, EV776124, JACYVU010000219, L18889
    UniProtKB/Swiss-Prot
    P35565
    Related
    ENSRNOP00000040859.4, ENSRNOT00000049942.4
    Conserved Domains (1) summary
    pfam00262
    Location:72441
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    34623865..34656866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767680.3XP_008765902.1  calnexin isoform X1

    See identical proteins and their annotated locations for XP_008765902.1

    UniProtKB/Swiss-Prot
    P35565
    Conserved Domains (1) summary
    pfam00262
    Location:72441
    Calreticulin; Calreticulin family
  2. XM_008767679.3XP_008765901.1  calnexin isoform X1

    See identical proteins and their annotated locations for XP_008765901.1

    UniProtKB/Swiss-Prot
    P35565
    Conserved Domains (1) summary
    pfam00262
    Location:72441
    Calreticulin; Calreticulin family
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