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Snx2 sorting nexin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291464, updated on 5-Mar-2024

Summary

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Official Symbol
Snx2provided by RGD
Official Full Name
sorting nexin 2provided by RGD
Primary source
RGD:1310291
See related
Ensembl:ENSRNOG00000017832 AllianceGenome:RGD:1310291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol binding activity; protein dimerization activity; and signaling receptor binding activity. Predicted to be involved in early endosome to Golgi transport and lamellipodium morphogenesis. Predicted to be located in lysosome and membrane. Predicted to be part of retromer, tubulation complex. Predicted to be active in endosome membrane. Orthologous to human SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 497.2), Spleen (RPKM 380.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (48800594..48842158)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (46602223..46643870)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (48132386..48173974)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483021 Neighboring gene aminomethyltransferase, pseudogene 1 Neighboring gene sorting nexin 24 Neighboring gene peptidylprolyl isomerase C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin. Lieu ZZ, et al. Eur J Cell Biol, 2010 May. PMID 20138391
  2. A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Prosser DC, et al. Traffic, 2010 Oct. PMID 20604901
  3. SNX26, a GTPase-activating protein for Cdc42, interacts with PSD-95 protein and is involved in activity-dependent dendritic spine formation in mature neurons. Kim Y, et al. J Biol Chem, 2013 Oct 11. PMID 24003235, Free PMC Article
  4. Determinants of the endosomal localization of sorting nexin 1. Zhong Q, et al. Mol Biol Cell, 2005 Apr. PMID 15673616, Free PMC Article
  5. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Haft CR, et al. Mol Biol Cell, 2000 Dec. PMID 11102511, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables leptin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in early endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
  
part_of retromer, tubulation complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sorting nexin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106135.2 → NP_001099605.2  sorting nexin-2

    See identical proteins and their annotated locations for NP_001099605.2

    Status: VALIDATED

    Source sequence(s)
    AI146078, CB557295, CO565239, CO567837, DV723418
    UniProtKB/TrEMBL
    A0A8I6A678, B2RYP4
    Related
    ENSRNOP00000051352.3, ENSRNOT00000050631.5
    Conserved Domains (4) summary
    cd07282
    Location:142 → 265
    PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
    COG5391
    Location:51 → 509
    COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]
    pfam03700
    Location:49 → 112
    Sorting_nexin; Sorting nexin, N-terminal domain
    cl12013
    Location:283 → 516
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    48800594..48842158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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