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Hpca hippocalcin [ Rattus norvegicus (Norway rat) ]

Gene ID: 29177, updated on 30-Mar-2024

Summary

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Official Symbol
Hpcaprovided by RGD
Official Full Name
hippocalcinprovided by RGD
Primary source
RGD:620060
See related
Ensembl:ENSRNOG00000006979 AllianceGenome:RGD:620060
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium ion binding activity and kinase binding activity. Involved in several processes, including activation of phospholipase D activity; cellular response to electrical stimulus; and negative regulation of guanylate cyclase activity. Located in several cellular components, including dendrite; neuronal cell body membrane; and perikaryon. Is extrinsic component of membrane. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in torsion dystonia 2. Orthologous to human HPCA (hippocalcin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 582.6) See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (146739978..146750961, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141455616..141466252, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (147295124..147305757, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 7-like Neighboring gene adenylate kinase 2 Neighboring gene uncharacterized LOC102551249 Neighboring gene ring finger protein 19B Neighboring gene transmembrane protein 54 Neighboring gene fibronectin type III domain containing 5 Neighboring gene S100P binding protein Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Perturbed Ca(2+)-dependent signaling of DYT2 hippocalcin mutant as mechanism of autosomal recessive dystonia. Osypenko DS, et al. Neurobiol Dis, 2019 Dec. PMID 31301343
  2. Diabetes aggravates decreases in hippocalcin and parvalbumin expression in focal cerebral ischemia. Park DJ, et al. Neurosci Lett, 2018 Jan 1. PMID 29061397
  3. Expression profiling shows differential molecular pathways and provides potential new diagnostic biomarkers for colorectal serrated adenocarcinoma. Conesa-Zamora P, et al. Int J Cancer, 2013 Jan 15. PMID 22696308
  4. Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Jo J, et al. Nat Neurosci, 2010 Oct. PMID 20852624
  5. Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons. Dovgan AV, et al. Eur J Neurosci, 2010 Aug. PMID 20704590, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Slow after hyperpolarization was identified as a downstream cellular target perturbed by a hippocalin mutation in DYT2 dystonia.
    Title: Perturbed Ca(2+)-dependent signaling of DYT2 hippocalcin mutant as mechanism of autosomal recessive dystonia.
  2. Study results suggest that significantly decreased levels of hippocalcin and parvalbumin exacerbate neuronal cell death in diabetic animals with ischemic brain injury.
    Title: Diabetes aggravates decreases in hippocalcin and parvalbumin expression in focal cerebral ischemia.
  3. These results indicate that Hpca associates with BB-CK and that together they translocate to membrane compartments in a Ca(2+)-dependent manner.
    Title: Hippocalcin mediates calcium-dependent translocation of brain-type creatine kinase (BB-CK) in hippocampal neurons.
  4. Suggest that the maintenance of parvalbumin and hippocalcin levels by melatonin in ischemic injury contributes to the neuroprotective effect of melatonin against neuronal cell damage.
    Title: Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury.
  5. hippocalcin may differentially decode patterns of glutamate receptor activation into site- and time-specific translocation to its targets. Hippocalcin can also produce local signaling at synapses providing a molecular mechanism for homosynaptic plasticity
    Title: Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons.
  6. Exhibits similar patterns of regulation during development and epileptogenesis
    Title: Overlapping microarray profiles of dentate gyrus gene expression during development- and epilepsy-associated neurogenesis and axon outgrowth.
  7. Taken together, these results suggest for the first time that hippocalcin can induce PLD2 expression and LPA potentiates hippocalcin-induced PLD2 expression, which is mediated by ERK activation.
    Title: Hippocalcin increases phospholipase D2 expression through extracellular signal-regulated kinase activation and lysophosphatidic acid potentiates the hippocalcin-induced phospholipase D2 expression.
  8. These data indicate that the AP2-hippocalcin complex acts as a Ca(2+) sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD.
    Title: Hippocalcin functions as a calcium sensor in hippocampal LTD.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC105450

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-mediated signaling IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to L-glutamate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to electrical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within inner ear development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to Aroclor 1254 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to L-glutamate IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ketamine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic spine head IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
neuron-specific calcium-binding protein hippocalcin
Names
P23K
calcium-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017122.2 → NP_058818.1  neuron-specific calcium-binding protein hippocalcin

    See identical proteins and their annotated locations for NP_058818.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P84076
    Related
    ENSRNOP00000009153.5, ENSRNOT00000009153.8
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    146739978..146750961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238920.4 → XP_006238982.1  neuron-specific calcium-binding protein hippocalcin isoform X1

    See identical proteins and their annotated locations for XP_006238982.1

    UniProtKB/Swiss-Prot
    P84076
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. XM_006238921.5 → XP_006238983.1  neuron-specific calcium-binding protein hippocalcin isoform X1

    See identical proteins and their annotated locations for XP_006238983.1

    UniProtKB/Swiss-Prot
    P84076
    Conserved Domains (1) summary
    COG5126
    Location:13 → 179
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84076.2 GenPept UniProtKB/Swiss-Prot:P84076

Gene LinkOut

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