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Aktip AKT interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 291906, updated on 11-Apr-2024

Summary

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Official Symbol
Aktipprovided by RGD
Official Full Name
AKT interacting proteinprovided by RGD
Primary source
RGD:1311170
See related
Ensembl:ENSRNOG00000011956 AllianceGenome:RGD:1311170
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fts
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within positive regulation of protein binding activity and positive regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of FHF complex. Predicted to be active in nucleus. Orthologous to human AKTIP (AKT interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 378.8), Brain (RPKM 292.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (32039507..32059634)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (15866811..15877123)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (17290048..17300054)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Rpgrip1-like Neighboring gene uncharacterized LOC134483615 Neighboring gene RB transcriptional corepressor like 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene chromodomain helicase DNA binding protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Xu L, et al. Mol Biol Cell, 2008 Dec. PMID 18799622, Free PMC Article
  2. Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Remy I, et al. Mol Cell Biol, 2004 Feb. PMID 14749367, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109405

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NEDD8 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in early endosome to late endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome to lysosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lysosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of FHF complex IEA
Inferred from Electronic Annotation
more info
  
part_of FHF complex ISO
Inferred from Sequence Orthology
more info
  
part_of FHF complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of HOPS complex IEA
Inferred from Electronic Annotation
more info
  
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AKT-interacting protein
Names
fused toes protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011926.1 → NP_001011926.1  AKT-interacting protein

    See identical proteins and their annotated locations for NP_001011926.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089985
    UniProtKB/Swiss-Prot
    Q5FVH4
    UniProtKB/TrEMBL
    A0A8I6GA43, A6KD80
    Related
    ENSRNOP00000092612.1, ENSRNOT00000109943.1
    Conserved Domains (1) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    32039507..32059634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601205.3 → XP_017456694.1  AKT-interacting protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GA43

  2. XM_017601206.2 → XP_017456695.1  AKT-interacting protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6GA43

  3. XM_006255182.5 → XP_006255244.1  AKT-interacting protein isoform X3

    See identical proteins and their annotated locations for XP_006255244.1

    UniProtKB/TrEMBL
    A0A8I6AQ33, A0A8I6GA43
    Conserved Domains (2) summary
    smart00212
    Location:79 → 222
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    COG5078
    Location:79 → 218
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

  4. XM_063277864.1 → XP_063133934.1  AKT-interacting protein isoform X4

    UniProtKB/Swiss-Prot
    Q5FVH4
    UniProtKB/TrEMBL
    A6KD80

  5. XM_063277863.1 → XP_063133933.1  AKT-interacting protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6AQ33

  6. XM_063277865.1 → XP_063133935.1  AKT-interacting protein isoform X5

    UniProtKB/TrEMBL
    A0A8I6AI00, A6KD77

  7. XM_039097569.2 → XP_038953497.1  AKT-interacting protein isoform X6

    Conserved Domains (1) summary
    smart00212
    Location:2 → 138
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVH4.1 GenPept UniProtKB/Swiss-Prot:Q5FVH4

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