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Nutf2 nuclear transport factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291981, updated on 13-Apr-2024

Summary

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Official Symbol
Nutf2provided by RGD
Official Full Name
nuclear transport factor 2provided by RGD
Primary source
RGD:1359213
See related
Ensembl:ENSRNOG00000018945 AllianceGenome:RGD:1359213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NTF2
Summary
Enables nuclear import signal receptor activity and small GTPase binding activity. Involved in negative regulation of vascular endothelial growth factor production; positive regulation of protein import into nucleus; and protein localization to nucleus. Located in cytosol and nuclear outer membrane. Part of nuclear pore central transport channel. Used to study diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 340.4), Heart (RPKM 243.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nutf2 in Genome Data Viewer
Location:
19q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50662168..50683457)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33752319..33773595)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37830917..37852192)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene translin-associated factor X interacting protein 1 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray diffraction analysis of nuclear transport factor 2. Kent HM, et al. J Struct Biol, 1996 Mar-Apr. PMID 8812990
  2. Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. Li B, et al. Mol Vis, 2009. PMID 19404486, Free PMC Article
  3. Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import. Kent HM, et al. J Mol Biol, 1999 Jun 11. PMID 10356329
  4. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. Steggerda SM, et al. Mol Biol Cell, 2000 Feb. PMID 10679025, Free PMC Article
  5. Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins p62 and Nsp1p. Clarkson WD, et al. J Mol Biol, 1996 Nov 8. PMID 8918934

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NTF2 is a potential mediator of retinal vasculature integrity.
    Title: Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72930

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nuclear pore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore central transport channel IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nuclear transport factor 2
Names
NTF-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007629.2 → NP_001007630.1  nuclear transport factor 2

    See identical proteins and their annotated locations for NP_001007630.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    P61972
    UniProtKB/TrEMBL
    A0A8L2QDH9, A6IYT2
    Related
    ENSRNOP00000025608.4, ENSRNOT00000025608.5
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50662168..50683457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255480.5 → XP_006255542.1  nuclear transport factor 2 isoform X1

    See identical proteins and their annotated locations for XP_006255542.1

    UniProtKB/Swiss-Prot
    P61972
    UniProtKB/TrEMBL
    A0A8L2QDH9, A6IYT2
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  2. XM_039097626.2 → XP_038953554.1  nuclear transport factor 2 isoform X1

    UniProtKB/Swiss-Prot
    P61972
    UniProtKB/TrEMBL
    A0A8L2QDH9, A6IYT2
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  3. XM_039097625.1 → XP_038953553.1  nuclear transport factor 2 isoform X1

    UniProtKB/Swiss-Prot
    P61972
    UniProtKB/TrEMBL
    A0A8L2QDH9, A6IYT2
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  4. XM_039097624.1 → XP_038953552.1  nuclear transport factor 2 isoform X1

    UniProtKB/Swiss-Prot
    P61972
    UniProtKB/TrEMBL
    A0A8L2QDH9, A6IYT2
    Related
    ENSRNOP00000080316.1, ENSRNOT00000101055.1
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61972.1 GenPept UniProtKB/Swiss-Prot:P61972

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