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Arg1 arginase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29221, updated on 13-Aug-2019

Summary

Official Symbol
Arg1provided by RGD
Official Full Name
arginase 1provided by RGD
Primary source
RGD:2150
See related
Ensembl:ENSRNOG00000013304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the hydrolysis of arginine to ornithine and urea in arginine metabolism; regulates nitric oxide production [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 3507.4) See more
Orthologs

Genomic context

See Arg1 in Genome Data Viewer
Location:
1p12
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (21525421..21537872)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (23005260..23017714)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552962 Neighboring gene uncharacterized LOC108349503 Neighboring gene mediator complex subunit 23 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
arginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginase activity IDA
Inferred from Direct Assay
more info
PubMed 
arginase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
arginine catabolic process to ornithine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginine catabolic process to ornithine IDA
Inferred from Direct Assay
more info
PubMed 
arginine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to glucagon stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-4 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to protozoan IEA
Inferred from Electronic Annotation
more info
 
defense response to protozoan ISO
Inferred from Sequence Orthology
more info
PubMed 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
liver development IEP
Inferred from Expression Pattern
more info
PubMed 
lung development IEP
Inferred from Expression Pattern
more info
PubMed 
mammary gland involution IEP
Inferred from Expression Pattern
more info
PubMed 
maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of T-helper 2 cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of interferon-gamma-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-gamma-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neutrophil mediated killing of fungus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neutrophil mediated killing of fungus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of L-arginine import IDA
Inferred from Direct Assay
more info
PubMed 
response to amine IEP
Inferred from Expression Pattern
more info
PubMed 
response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to axon injury IEP
Inferred from Expression Pattern
more info
PubMed 
response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to herbicide IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to methylmercury IEP
Inferred from Expression Pattern
more info
PubMed 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to selenium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
urea cycle IDA
Inferred from Direct Assay
more info
PubMed 
urea cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arginase-1
Names
AI type I arginase
arginase, liver
liver-type arginase
type I arginase
NP_058830.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017134.3NP_058830.2  arginase-1

    See identical proteins and their annotated locations for NP_058830.2

    Status: VALIDATED

    Source sequence(s)
    AC139610, FM100195, FM120421
    UniProtKB/Swiss-Prot
    P07824
    Related
    ENSRNOP00000017911.2, ENSRNOT00000017911.5
    Conserved Domains (1) summary
    cd11587
    Location:9303
    Arginase-like; Arginase types I and II and arginase-like family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    21525421..21537872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    19228309..19241078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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