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Ak4 adenylate kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29223, updated on 11-Apr-2024

Summary

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Official Symbol
Ak4provided by RGD
Official Full Name
adenylate kinase 4provided by RGD
Primary source
RGD:2078
See related
Ensembl:ENSRNOG00000045738 AllianceGenome:RGD:2078
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AK 4; Ak3l1; Ak3l2
Summary
Predicted to enable adenylate kinase activity; nucleoside diphosphate kinase activity; and nucleoside triphosphate adenylate kinase activity. Involved in brain development; liver development; and response to xenobiotic stimulus. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Biomarker of acute kidney tubular necrosis. Orthologous to human AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1264.8), Liver (RPKM 558.2) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ak4 in Genome Data Viewer
Location:
5q33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (121154565..121214403)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (116039222..116099064)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (120250318..120309153)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479017 Neighboring gene ribosomal protein L9, pseudogene 16 Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene uncharacterized LOC134479018 Neighboring gene uncharacterized LOC120102936

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants. Yamamoto T, et al. J Toxicol Sci, 2006 Feb. PMID 16538043
  2. Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis. Jan YH, et al. J Hematol Oncol, 2019 Jan 29. PMID 30696468, Free PMC Article
  3. Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4. Fujisawa K, et al. J Exp Clin Cancer Res, 2016 Mar 16. PMID 26980435, Free PMC Article
  4. A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels. Lanning NJ, et al. Cell Rep, 2014 May 8. PMID 24767988, Free PMC Article
  5. Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells. Kong F, et al. Arch Biochem Biophys, 2013 May. PMID 23474458

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage.
    Title: MicroRNA-124 conducts neuroprotective effect via inhibiting AK4/ATF3 after subarachnoid hemorrhage.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93541

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleoside triphosphate adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables nucleoside triphosphate adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside triphosphate adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ADP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in AMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in AMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in AMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GTP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside triphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of oxidative phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in ribonucleoside diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ribonucleoside diphosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylate kinase 4, mitochondrial
Names
ATP-AMP transphosphorylase
GTP:AMP phosphotransferase AK4, mitochondrial
adenylate kinase 3 alpha-like 1
adenylate kinase 3-like 1
adenylate kinase 3-like 2
adenylate kinase isoenzyme 4, mitochondrial
NP_058831.1
XP_017448685.1
XP_038965281.1
XP_063143316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017135.3 → NP_058831.1  adenylate kinase 4, mitochondrial

    See identical proteins and their annotated locations for NP_058831.1

    Status: PROVISIONAL

    Source sequence(s)
    D87809
    UniProtKB/Swiss-Prot
    Q9WUS0
    UniProtKB/TrEMBL
    A0A8L2QYP3
    Conserved Domains (1) summary
    TIGR01351
    Location:7 → 211
    adk; adenylate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    121154565..121214403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593196.3 → XP_017448685.1  adenylate kinase 4, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9WUS0
    UniProtKB/TrEMBL
    A0A8L2QYP3
    Related
    ENSRNOP00000065349.2
    Conserved Domains (1) summary
    TIGR01351
    Location:7 → 211
    adk; adenylate kinase

  2. XM_063287246.1 → XP_063143316.1  adenylate kinase 4, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9WUS0

  3. XM_039109353.2 → XP_038965281.1  adenylate kinase 4, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A6JRN6
    Conserved Domains (1) summary
    pfam00406
    Location:1 → 116
    ADK; Adenylate kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUS0.1 GenPept UniProtKB/Swiss-Prot:Q9WUS0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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