Tnni3 troponin I3, cardiac type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnni3provided by RGD
Official Full Name: troponin I3, cardiac typeprovided by RGD
Primary source: RGD:62052
See related: Ensembl:ENSRNOG00000018250 AllianceGenome:RGD:62052
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TnI; cTNI
Summary: Predicted to enable several functions, including calcium channel inhibitor activity; calcium-dependent protein binding activity; and cytoskeletal protein binding activity. Involved in cardiac muscle contraction and regulation of smooth muscle contraction. Located in sarcomere. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 28983.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (78342571..78346255)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (69299900..69303582)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (72882806..72886490)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise-induced alterations of myocardial sarcomere dynamics are associated with hypophosphorylation of cardiac troponin I.
Title: Exercise-induced alterations of myocardial sarcomere dynamics are associated with hypophosphorylation of cardiac troponin I.
Phosphorylation of Troponin I finely controls the positioning of Troponin for the optimal regulation of cardiac muscle contraction.
Title: Phosphorylation of Troponin I finely controls the positioning of Troponin for the optimal regulation of cardiac muscle contraction.
MiR-449 improves cardiac function by regulating HDAC1 and cTnI.
Title: MiR-449 improves cardiac function by regulating HDAC1 and cTnI.
Altered expression levels of autophagy-associated proteins during exercise preconditioning indicate the involvement of autophagy in cardioprotection against exercise-induced myocardial injury.
Title: Altered expression levels of autophagy-associated proteins during exercise preconditioning indicate the involvement of autophagy in cardioprotection against exercise-induced myocardial injury.
TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility
Title: TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility.
the significant role of cTnI-MD in the length dependent thin filament activation and the coupling between thin and thick filament regulations affected by SL
Title: Role of the C-terminus mobile domain of cardiac troponin I in the regulation of thin filament activation in skinned papillary muscle strips.
Pim-1 is a novel kinase that phosphorylates cTnI primarily at Ser23/24 and Ser150 in cardiomyocytes, which in turn may modulate myofilament function under a variety of physiological and pathophysiological conditions.
Title: Pim-1 Kinase Phosphorylates Cardiac Troponin I and Regulates Cardiac Myofilament Function.
Cardiac troponin I mutation P83S present in hypertrophic cardiomyopathy changes the contractile myofibril properties and modulation by PKA-mediated phosphorylation.
Title: Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation.
Troponin I interaction with calcium and Troponin C in cardiac muscle
Title: The concerted movement of the switch region of Troponin I in cardiac muscle thin filaments as tracked by conventional and pulsed (DEER) EPR.
Compared to cTnI(WT), both truncations displayed greater Ca(2+)-sensitivity and faster cross-bridge attachment rates at both SLs. Furthermore, cTnI(1-167) slowed MgADP release rate and enhanced cross-bridge binding. Our findings imply that cTnI-MD truncations affect the blocked-to closed-state transition(s) and destabilize the closed-state position of tropomyosin.
Title: Functional significance of C-terminal mobile domain of cardiac troponin I.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139764 (e-PCR)
- UniSTS:221848

D1Wox56 (e-PCR)
- UniSTS:239562

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calcium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables troponin C binding	ISO Inferred from Sequence Orthology more info
enables troponin T binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of systemic arterial blood pressure by ischemic conditions	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within striated muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cardiac Troponin complex	ISO Inferred from Sequence Orthology more info
located_in cardiac myofibril	ISO Inferred from Sequence Orthology more info
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in sarcomere	ISO Inferred from Sequence Orthology more info
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IEA Inferred from Electronic Annotation more info
part_of troponin complex	ISO Inferred from Sequence Orthology more info
part_of troponin complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: troponin I, cardiac muscle

Names: cardiac troponin I; troponin 1, type 3; troponin I type 3 (cardiac)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017144.2 → NP_058840.1 troponin I, cardiac muscle

See identical proteins and their annotated locations for NP_058840.1

Status: PROVISIONAL

Source sequence(s)

X58499

UniProtKB/Swiss-Prot

P23693, Q4PP23

UniProtKB/TrEMBL

A0A8I6ADH6

Related

ENSRNOP00000024640.3, ENSRNOT00000024640.6

Conserved Domains (2) summary

pfam11636
Location:4 → 32

Troponin-I_N; Troponin I residues 1-32

pfam00992
Location:47 → 178

Troponin; Troponin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

78342571..78346255

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282921.1 → XP_063138991.1 troponin I, cardiac muscle isoform X1
XM_039103599.2 → XP_038959527.1 troponin I, cardiac muscle isoform X2

UniProtKB/TrEMBL

A6KNL9

Conserved Domains (1) summary

pfam00992
Location:28 → 159

Troponin