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Zfp444 zinc finger protein 444 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292569, updated on 30-Mar-2024

Summary

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Official Symbol
Zfp444provided by RGD
Official Full Name
zinc finger protein 444provided by RGD
Primary source
RGD:1304847
See related
Ensembl:ENSRNOG00000015517 AllianceGenome:RGD:1304847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf444
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF444 (zinc finger protein 444). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 118.3), Kidney (RPKM 97.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (76741399..76762388, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (67709052..67729283, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (71380856..71400781, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 5B Neighboring gene galanin-like peptide Neighboring gene zinc finger protein 787 Neighboring gene NLR family, pyrin domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 444

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169143.1 → NP_001162614.1  zinc finger protein 444

    See identical proteins and their annotated locations for NP_001162614.1

    Status: VALIDATED

    Source sequence(s)
    FM030255, JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KS79, D3ZV88
    Related
    ENSRNOP00000020787.4, ENSRNOT00000020787.7
    Conserved Domains (4) summary
    COG5048
    Location:188 → 286
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:26 → 103
    SCAN; SCAN domain
    pfam13465
    Location:202 → 227
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    76741399..76762388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228186.5 → XP_006228248.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_006228248.1

    UniProtKB/TrEMBL
    A6KS79, D3ZV88
    Conserved Domains (4) summary
    COG5048
    Location:188 → 286
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:26 → 103
    SCAN; SCAN domain
    pfam13465
    Location:202 → 227
    zf-H2C2_2; Zinc-finger double domain

  2. XM_008758902.4 → XP_008757124.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_008757124.1

    UniProtKB/TrEMBL
    A6KS79, D3ZV88
    Conserved Domains (4) summary
    COG5048
    Location:188 → 286
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:26 → 103
    SCAN; SCAN domain
    pfam13465
    Location:202 → 227
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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