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Zfp536 zinc finger protein 536 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292820, updated on 13-Apr-2024

Summary

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Official Symbol
Zfp536provided by RGD
Official Full Name
zinc finger protein 536provided by RGD
Primary source
RGD:1563363
See related
Ensembl:ENSRNOG00000014163 AllianceGenome:RGD:1563363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf536; RGD1563363
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and retinoic acid-responsive element binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of neuron differentiation and negative regulation of retinoic acid receptor signaling pathway. Predicted to be active in nucleus. Orthologous to human ZNF536 (zinc finger protein 536). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 38.0), Adrenal (RPKM 18.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp536 in Genome Data Viewer
Location:
1q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (99137133..99600379, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (90000359..90463423, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (93689114..94155457, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27A like 3 Neighboring gene uncharacterized LOC134484891 Neighboring gene uncharacterized LOC108349103 Neighboring gene histidine-rich glycoprotein-like Neighboring gene uncharacterized LOC134485112 Neighboring gene U6 spliceosomal RNA Neighboring gene URI1, prefoldin-like chaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ZNF536, a novel zinc finger protein specifically expressed in the brain, negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. Qin Z, et al. Mol Cell Biol, 2009 Jul. PMID 19398580, Free PMC Article
  2. Functional genomic analysis of oligodendrocyte differentiation. Dugas JC, et al. J Neurosci, 2006 Oct 25. PMID 17065439, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFP536 promotes the late phase of oligodendrocyte differentiation
    Title: Functional genomic analysis of oligodendrocyte differentiation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid-responsive element binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 536

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427135.1 → NP_001414064.1  zinc finger protein 536

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZJS6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    99137133..99600379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283757.1 → XP_063139827.1  zinc finger protein 536 isoform X1

    UniProtKB/TrEMBL
    D3ZJS6

  2. XM_008759270.4 → XP_008757492.2  zinc finger protein 536 isoform X1

    UniProtKB/TrEMBL
    D3ZJS6
    Related
    ENSRNOP00000018956.5
    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  3. XM_063283740.1 → XP_063139810.1  zinc finger protein 536 isoform X1

    UniProtKB/TrEMBL
    D3ZJS6

  4. XM_063283747.1 → XP_063139817.1  zinc finger protein 536 isoform X1

    UniProtKB/TrEMBL
    D3ZJS6

  5. XM_063283750.1 → XP_063139820.1  zinc finger protein 536 isoform X1

    UniProtKB/TrEMBL
    D3ZJS6

  6. XM_063283762.1 → XP_063139832.1  zinc finger protein 536 isoform X1

    UniProtKB/TrEMBL
    D3ZJS6

  7. XM_008759271.4 → XP_008757493.2  zinc finger protein 536 isoform X1

    UniProtKB/TrEMBL
    D3ZJS6
    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  8. XM_008759269.4 → XP_008757491.2  zinc finger protein 536 isoform X1

    UniProtKB/TrEMBL
    D3ZJS6
    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  9. XM_039100867.2 → XP_038956795.1  zinc finger protein 536 isoform X1

    UniProtKB/TrEMBL
    D3ZJS6
    Conserved Domains (6) summary
    COG5048
    Location:103 → 180
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:755 → 775
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:767 → 789
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:781 → 804
    zf-H2C2_5; C2H2-type zinc-finger domain
    pfam16606
    Location:657 → 739
    zf-C2H2_assoc; Unstructured conserved, between two C2H2-type zinc-fingers

  10. XM_063283777.1 → XP_063139847.1  zinc finger protein 536 isoform X3

  11. XM_063283767.1 → XP_063139837.1  zinc finger protein 536 isoform X2

  12. XM_063283764.1 → XP_063139834.1  zinc finger protein 536 isoform X2

  13. XM_063283773.1 → XP_063139843.1  zinc finger protein 536 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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