U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Crebzf CREB/ATF bZIP transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 293112, updated on 13-Apr-2024

Summary

Official Symbol
Crebzfprovided by RGD
Official Full Name
CREB/ATF bZIP transcription factorprovided by RGD
Primary source
RGD:1565584
See related
Ensembl:ENSRNOG00000018987 AllianceGenome:RGD:1565584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565584
Summary
Predicted to enable identical protein binding activity and transcription cis-regulatory region binding activity. Predicted to be involved in negative regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; and response to virus. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CREBZF (CREB/ATF bZIP transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 145.3), Spleen (RPKM 119.6) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
1q32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (153829544..153836073)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (144416864..144423540)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (156290215..156296891, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 2 Neighboring gene coiled-coil domain containing 89 Neighboring gene transmembrane protein 126A Neighboring gene transmembrane protein 126B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CREB/ATF bZIP transcription factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271791.1NP_001258720.1  CREB/ATF bZIP transcription factor

    See identical proteins and their annotated locations for NP_001258720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    FN797334, JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6G6F0, A6I638
    Related
    ENSRNOP00000081742.1, ENSRNOT00000104785.1
    Conserved Domains (1) summary
    cl21462
    Location:220261
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RNA

  1. NR_073439.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    JAXUCZ010000001
  2. NR_073440.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    JAXUCZ010000001
  3. NR_073441.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    153829544..153836073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759646.3XP_008757868.1  CREB/ATF bZIP transcription factor isoform X1

    See identical proteins and their annotated locations for XP_008757868.1

    UniProtKB/TrEMBL
    A6I636, D3ZU42
    Related
    ENSRNOP00000025653.3
    Conserved Domains (1) summary
    cl21462
    Location:220261
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain