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Art2b ADP-ribosyltransferase 2b [ Rattus norvegicus (Norway rat) ]

Gene ID: 293152, updated on 13-Apr-2024

Summary

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Official Symbol
Art2bprovided by RGD
Official Full Name
ADP-ribosyltransferase 2bprovided by RGD
Primary source
RGD:3521
See related
Ensembl:ENSRNOG00000019687 AllianceGenome:RGD:3521
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LY2; Rt6; Ag-F; Art2; Ly-2; PtaA; ARTC2; Art2a; RT6.1; RT6.2
Summary
Enables NAD(P)+-protein-arginine ADP-ribosyltransferase activity. Predicted to be involved in NAD catabolic process and peptidyl-arginine ADP-ribosylation. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 89.3), Thymus (RPKM 44.3) and 2 other tissues See more
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Genomic context

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Location:
1q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165368623..165386280, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (155956601..155974252, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166665029..166685097, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097347 Neighboring gene phosphodiesterase 2A Neighboring gene microRNA 139 Neighboring gene uncharacterized LOC120099897 Neighboring gene lactate dehydrogenase A, pseudogene 3 Neighboring gene ClpB family mitochondrial disaggregase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). Morrison AR, et al. J Biol Chem, 2006 Nov 3. PMID 16931513
  2. Regulatory role of arginine 204 in the catalytic activity of rat alloantigens ART2a and ART2b. Stevens LA, et al. J Biol Chem, 2003 May 30. PMID 12649291
  3. Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat. Mueller-Dieckmann C, et al. J Mol Biol, 2002 Sep 27. PMID 12270706
  4. Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus. Rothenburg S, et al. J Mol Evol, 2002 Sep. PMID 12187378
  5. Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2). Mueller-Dieckmann C, et al. Acta Crystallogr D Biol Crystallogr, 2002 Jul. PMID 12077446

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression, purification, crystallization and X-ray analysis
    Title: Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2).
  2. Our data indicate that the RT6 alleles diverged about 1 myr ago and that the ID element integrated into the RT6a locus soon after this.
    Title: Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus.
  3. capability of polymerizing ADP-ribose may not be unique to poly(ADP-ribose) polymerases and that poly(ADP-ribosylation), an established nuclear activity, may occur extracellularly and modulate cell function
    Title: ART2, a T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose).
  4. Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat.
    Title: Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC116041

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity, acting on glycosyl bonds ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-cell ecto-ADP-ribosyltransferase 2
Names
ADP-ribosyltransferase 2
ADP-ribosyltransferase 2a
ADP-ribosyltransferase C2 and C3 toxin-like 2
Cell surface alloantigen peripheral T-cell antigen
NAD(+) glycohydrolase
T cell differentiation marker RT6.1
T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1
T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2
T-cell ecto-ADP-ribosyltransferase 1
T-cell mono(ADP-ribosyl)transferase 1
T-cell mono(ADP-ribosyl)transferase 2
T-cell surface protein Rt6.1
T-cell surface protein Rt6.2
alloantigen Rt6.1
alloantigen Rt6.2
cell surface alloantigen 6
mono(ADP-ribosyl)transferase 2A
mono(ADP-ribosyl)transferase 2B
NP_942030.1
XP_017444448.1
XP_038962041.1
XP_063141259.1
XP_063141264.1
XP_063141266.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198735.3 → NP_942030.1  T-cell ecto-ADP-ribosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_942030.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P17982, P20974, P97912, Q4FZV8, Q95576, Q9EPH9
    UniProtKB/TrEMBL
    A6I6V2
    Conserved Domains (1) summary
    pfam01129
    Location:27 → 239
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    165368623..165386280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285189.1 → XP_063141259.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUJ8

  2. XM_017588959.3 → XP_017444448.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

    UniProtKB/Swiss-Prot
    P17982, P20974, P97912, Q4FZV8, Q95576, Q9EPH9
    UniProtKB/TrEMBL
    A6I6V2
    Related
    ENSRNOP00000026644.4
    Conserved Domains (1) summary
    pfam01129
    Location:27 → 239
    ART; NAD:arginine ADP-ribosyltransferase

  3. XM_039106113.2 → XP_038962041.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

    UniProtKB/Swiss-Prot
    P17982, P20974, P97912, Q4FZV8, Q95576, Q9EPH9
    UniProtKB/TrEMBL
    A6I6V2
    Related
    ENSRNOP00000069125.1
    Conserved Domains (1) summary
    pfam01129
    Location:27 → 239
    ART; NAD:arginine ADP-ribosyltransferase

  4. XM_063285196.1 → XP_063141266.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

    UniProtKB/Swiss-Prot
    P20974, P97912, Q4FZV8, Q95576, Q9EPH9
    UniProtKB/TrEMBL
    A6I6V2

  5. XM_063285194.1 → XP_063141264.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

    UniProtKB/Swiss-Prot
    P20974, P97912, Q4FZV8, Q95576, Q9EPH9
    UniProtKB/TrEMBL
    A6I6V2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17982.1 GenPept UniProtKB/Swiss-Prot:P17982
P20974.2 GenPept UniProtKB/Swiss-Prot:P20974

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