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Plcb3 phospholipase C beta 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29322, updated on 11-Apr-2024

Summary

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Official Symbol
Plcb3provided by RGD
Official Full Name
phospholipase C beta 3provided by RGD
Primary source
RGD:61993
See related
Ensembl:ENSRNOG00000021150 AllianceGenome:RGD:61993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phosphatidylinositol phospholipase C activity. Involved in several processes, including inositol trisphosphate metabolic process; phosphatidylinositol catabolic process; and phosphatidylinositol-mediated signaling. Located in cytosol and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (phospholipase C beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 97.1), Adrenal (RPKM 78.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213572499..213589585, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204143257..204160384, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222207887..222224993, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 137 Neighboring gene BCL2-associated agonist of cell death Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B Neighboring gene FKBP prolyl isomerase 2 like 1 Neighboring gene FKBP prolyl isomerase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Aortic constriction induces hypertension and cardiac hypertrophy via (pro)renin receptor activation and the PLC‑β3 signaling pathway. Wu J, et al. Mol Med Rep, 2019 Jan. PMID 30431106
  2. Defective sarcolemmal phospholipase C signaling in diabetic cardiomyopathy. Tappia PS, et al. Mol Cell Biochem, 2004 Jun. PMID 15362504
  3. The 5'-upstream region of the rat phospholipase C-beta 3 gene contains two critical Sp1 sites and an HIV Inr-like element. Kang JS, et al. Gene, 1997 Sep 15. PMID 9332346
  4. Phospholipase Cbeta3 is distributed in both somatodendritic and axonal compartments and localized around perisynapse and smooth endoplasmic reticulum in mouse Purkinje cell subsets. Nomura S, et al. Eur J Neurosci, 2007 Feb. PMID 17298601
  5. Targeted disruption of the mouse phospholipase C beta3 gene results in early embryonic lethality. Wang S, et al. FEBS Lett, 1998 Dec 18. PMID 9883896

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High phospholipase C beta 3 expression is associated with hypertension and cardiac hypertrophy.
    Title: Aortic constriction induces hypertension and cardiac hypertrophy via (pro)renin receptor activation and the PLC‑β3 signaling pathway.
  2. Silencing of either c-Fos or c-Jun also depressed the norepinephrine-mediated increases in PLC beta(1), beta(3) and gamma(1) protein content and activity in an isozyme specific manner.
    Title: Reciprocal regulation of transcription factors and PLC isozyme gene expression in adult cardiomyocytes.
  3. Phosphorylation of Pthr1 at Ser1105 is demonstrated as a regulatory mechanism of PLCbeta3 by PKA.
    Title: Negative regulation of parathyroid hormone (PTH)-activated phospholipase C by PTH/PTH-related peptide receptor phosphorylation and protein kinase A.
  4. Shank2 brings PLC-beta3 closer to Homer 1b and constitutes an efficient mGluR-coupled signaling pathway in the PSD region of neuronal synapses
    Title: The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase C activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inositol trisphosphate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in post-Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Names
PLC-beta-3
phosphoinositide phospholipase C-beta-3
phospholipase C, beta 3 (phosphatidylinositol-specific)
NP_203501.1
XP_006230773.1
XP_038962492.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033350.1 → NP_203501.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

    See identical proteins and their annotated locations for NP_203501.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ120508
    UniProtKB/Swiss-Prot
    Q62887, Q99JE6, Q9QW29
    UniProtKB/TrEMBL
    F7FBZ0, Q45QJ4
    Related
    ENSRNOP00000028720.5, ENSRNOT00000028720.7
    Conserved Domains (7) summary
    cd00275
    Location:729 → 844
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:316 → 694
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:22 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam02050
    Location:1031 → 1103
    FliJ; Flagellar FliJ protein
    pfam06631
    Location:952 → 989
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1032 → 1204
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:225 → 315
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213572499..213589585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230711.5 → XP_006230773.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1

    See identical proteins and their annotated locations for XP_006230773.1

    UniProtKB/Swiss-Prot
    Q62887, Q99JE6, Q9QW29
    UniProtKB/TrEMBL
    F7FBZ0, Q45QJ4
    Conserved Domains (7) summary
    cd00275
    Location:729 → 844
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:316 → 694
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:22 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam02050
    Location:1031 → 1103
    FliJ; Flagellar FliJ protein
    pfam06631
    Location:952 → 989
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1032 → 1204
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:225 → 315
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  2. XM_039106564.2 → XP_038962492.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2

    Conserved Domains (3) summary
    cd08591
    Location:316 → 682
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:22 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16210
    Location:154 → 304
    EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JE6.2 GenPept UniProtKB/Swiss-Prot:Q99JE6

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