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Hbs1l HBS1-like translational GTPase [ Rattus norvegicus (Norway rat) ]

Gene ID: 293408, updated on 5-Mar-2024

Summary

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Official Symbol
Hbs1lprovided by RGD
Official Full Name
HBS1-like translational GTPaseprovided by RGD
Primary source
RGD:1308509
See related
Ensembl:ENSRNOG00000014531 AllianceGenome:RGD:1308509
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activity. Predicted to be involved in translation. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 346.5), Heart (RPKM 343.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hbs1l in Genome Data Viewer
Location:
1p12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (17912139..17989651)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (16092529..16170082)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (16819170..16896234)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484958 Neighboring gene uncharacterized LOC134484960 Neighboring gene uncharacterized LOC134484961 Neighboring gene ribosomal protein L23a, pseudogene 3 Neighboring gene aldehyde dehydrogenase 8 family, member A1 Neighboring gene protein LEG1 homolog Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Association of SNP in exon 1 of HBS1L with hemoglobin F level in beta0-thalassemia/hemoglobin E. Pandit RA, et al. Int J Hematol, 2008 Nov. PMID 18839276
  2. Structural view on recycling of archaeal and eukaryotic ribosomes after canonical termination and ribosome rescue. Franckenberg S, et al. Curr Opin Struct Biol, 2012 Dec. PMID 23031510
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in nuclear-transcribed mRNA catabolic process, no-go decay ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, no-go decay ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Dom34-Hbs1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Dom34-Hbs1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HBS1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011934.1 → NP_001011934.1  HBS1-like protein

    See identical proteins and their annotated locations for NP_001011934.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079463
    UniProtKB/Swiss-Prot
    Q6AXM7
    UniProtKB/TrEMBL
    A0A8I6AGM5
    Related
    ENSRNOP00000019734.7, ENSRNOT00000019734.8
    Conserved Domains (5) summary
    cd01883
    Location:257 → 476
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:251 → 679
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam08938
    Location:45 → 119
    HBS1_N; HBS1 N-terminus
    cd16267
    Location:482 → 564
    HBS1-like_II; Domain II of Hbs1-like proteins
    cd04093
    Location:569 → 677
    HBS1_C_III; C-terminal domain of Hsp70 subfamily B suppressor 1 (HBS1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    17912139..17989651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285773.1 → XP_063141843.1  HBS1-like protein isoform X1

  2. XM_039106903.2 → XP_038962831.1  HBS1-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6AGM5, A6JPD9
    Conserved Domains (2) summary
    COG5256
    Location:254 → 682
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam08938
    Location:45 → 119
    HBS1_N; HBS1 N-terminus

  3. XM_063285777.1 → XP_063141847.1  HBS1-like protein isoform X3

  4. XM_039106909.2 → XP_038962837.1  HBS1-like protein isoform X4

    UniProtKB/TrEMBL
    A0A8I6AGM5, A0A8I6GEG8
    Related
    ENSRNOP00000086834.1
    Conserved Domains (1) summary
    COG5256
    Location:189 → 617
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

  5. XM_039106912.2 → XP_038962840.1  HBS1-like protein isoform X5

    UniProtKB/TrEMBL
    A0A8I6GEM5
    Related
    ENSRNOP00000086972.1
    Conserved Domains (1) summary
    pfam08938
    Location:45 → 119
    HBS1_N; HBS1 N-terminus

  6. XM_063285786.1 → XP_063141856.1  HBS1-like protein isoform X6

  7. XM_063285789.1 → XP_063141859.1  HBS1-like protein isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXM7.1 GenPept UniProtKB/Swiss-Prot:Q6AXM7

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