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Fgf7 fibroblast growth factor 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29348, updated on 13-Aug-2019

Summary

Official Symbol
Fgf7provided by RGD
Official Full Name
fibroblast growth factor 7provided by RGD
Primary source
RGD:61805
See related
Ensembl:ENSRNOG00000009425
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kgf; KGF/FGF7
Summary
mediates glucocorticoid induction of fetal lung maturation; involved in regulation of surfactant synthesis [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 81.8), Lung (RPKM 48.2) and 9 other tissues See more
Orthologs

Genomic context

See Fgf7 in Genome Data Viewer
Location:
3q36
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118315859..118368464)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (124840157..124892611)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene TATA element modulatory factor-like Neighboring gene SECIS binding protein 2-like Neighboring gene COP9 signalosome subunit 2 Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene DTW domain containing 1 Neighboring gene ATPase phospholipid transporting 8B4 (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chemoattractant activity IEA
Inferred from Electronic Annotation
more info
 
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
PubMed 
fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
type 2 fibroblast growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
PubMed 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylcholine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of epithelial cell proliferation involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of keratinocyte migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
secretion by lung epithelial cell involved in lung growth IEA
Inferred from Electronic Annotation
more info
 
secretion by lung epithelial cell involved in lung growth ISO
Inferred from Sequence Orthology
more info
PubMed 
surfactant homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor 7
Names
FGF-7
HBGF-7
Keratinocyte Growth Factor Fgf-7
heparin-binding growth factor 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022182.1NP_071518.1  fibroblast growth factor 7 precursor

    See identical proteins and their annotated locations for NP_071518.1

    Status: PROVISIONAL

    Source sequence(s)
    X56551
    UniProtKB/Swiss-Prot
    Q02195
    Related
    ENSRNOP00000012700.2, ENSRNOT00000012700.4
    Conserved Domains (1) summary
    smart00442
    Location:63191
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    118315859..118368464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591518.1XP_017447007.1  fibroblast growth factor 7 isoform X1

    UniProtKB/TrEMBL
    G3V775
    Conserved Domains (1) summary
    smart00442
    Location:63191
    FGF; Acidic and basic fibroblast growth factor family
  2. XM_006234903.3XP_006234965.1  fibroblast growth factor 7 isoform X1

    See identical proteins and their annotated locations for XP_006234965.1

    UniProtKB/TrEMBL
    G3V775
    Conserved Domains (1) summary
    smart00442
    Location:63191
    FGF; Acidic and basic fibroblast growth factor family

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    112134799..112183941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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