Fgf7 fibroblast growth factor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgf7provided by RGD
Official Full Name: fibroblast growth factor 7provided by RGD
Primary source: RGD:61805
See related: Ensembl:ENSRNOG00000009425 AllianceGenome:RGD:61805
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kgf; Fgf5b; KGF/FGF7
Summary: Enables growth factor activity; heparin binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including ovarian follicle development; phosphatidylcholine biosynthetic process; and surfactant homeostasis. Located in extracellular space. Orthologous to human FGF7 (fibroblast growth factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 81.8), Lung (RPKM 48.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (133734557..133786678)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (113280448..113333279)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (118315859..118368464)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of Taspine hydrochloride on the repair of rat skin wounds by regulating keratinocyte growth factor signal.
Title: Effect of Taspine hydrochloride on the repair of rat skin wounds by regulating keratinocyte growth factor signal.
MiR-199a-3p inhibits the proliferation, migration, and invasion of endothelial cells and retinal pericytes of diabetic retinopathy rats through regulating FGF7 via EGFR/PI3K/AKT pathway.
Title: MiR-199a-3p inhibits the proliferation, migration, and invasion of endothelial cells and retinal pericytes of diabetic retinopathy rats through regulating FGF7 via EGFR/PI3K/AKT pathway.
Silencing fibroblast growth factor 7 inhibits krypton laser-induced choroidal neovascularization in a rat model.
Title: Silencing fibroblast growth factor 7 inhibits krypton laser-induced choroidal neovascularization in a rat model.
findings illustrate a role for miR-455-3p-1 in modulating FGF7-RAS/ERK signaling and suggest that an agomir of miR-455-3p-1 could inhibit the proliferation of PASMCs and mitigate PAH in vivo.
Title: Mir-455-3p-1 represses FGF7 expression to inhibit pulmonary arterial hypertension through inhibiting the RAS/ERK signaling pathway.
findings demonstrate that KGF-1 promotes fibroblast contraction and accelerates wound contraction via the TGF-beta1/Smad signaling pathway in a double-paracrine manner.
Title: KGF-1 accelerates wound contraction through the TGF-β1/Smad signaling pathway in a double-paracrine manner.
HGF and KGF gene silencing inhibits ultraviolet raysinduced corneal epithelial proliferation and corneal neovascularization and may function as novel targets for corneal wound healing.
Title: Effects of HGF and KGF gene silencing on vascular endothelial growth factor and its receptors in rat ultraviolet radiation‑induced corneal neovascularization.
The findings of the present study indicated that KGF, CTGF and TGF-beta have biological roles in progression of CsA- and PNT- induced GO. KGF plays a greater role in CsA- induced GO than in PNT- induced GO. Meanwhile, CTGF and TGF-beta play a role in PNT- induced GO greater than in CsA- induced GO.
Title: Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study.
These data demonstrate that administration of MSCs to the inflammation-insulted AT-II cells may ameliorate the impairments through a KGF-dependent PI3K/AKT/mTOR signaling pathway.
Title: Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway.
The primary role of both KGF1 and FGF2 appeared to be in the proliferation and migration of keratinocytes
Title: Keratinocyte growth factor 1, fibroblast growth factor 2 and 10 in the healing tympanic membrane following perforation in rats.
KGF may have a role in ameliorating radiation-induced pulmonary injury in rats
Title: Keratinocyte growth factor (KGF) gene therapy mediated by an attenuated form of Salmonella typhimurium ameliorates radiation induced pulmonary injury in rats.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Markers

Fgf7 (e-PCR), detects polymorphism
- UniSTS:546579

D3Mco11 (e-PCR)
- UniSTS:239905

FGF7 (e-PCR)
- UniSTS:273722

Fgf7 (e-PCR), detects polymorphism
- UniSTS:273722

Fgf7 (e-PCR), detects polymorphism
- UniSTS:547901

Fgf7 (e-PCR), detects polymorphism
- UniSTS:265078

FGF7 (e-PCR)
- UniSTS:253915

Fgf7 (e-PCR), detects polymorphism
- UniSTS:258273

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables type 2 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 2 fibroblast growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in branching involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hair follicle morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lung development	IBA Inferred from Biological aspect of Ancestor more info
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of keratinocyte migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in secretion by lung epithelial cell involved in lung growth	IEA Inferred from Electronic Annotation more info
involved_in secretion by lung epithelial cell involved in lung growth	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 7

Names: FGF-7; HBGF-7; Keratinocyte Growth Factor Fgf-7; fibroblast growth factor 5b; heparin-binding growth factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022182.1 → NP_071518.1 fibroblast growth factor 7 precursor

See identical proteins and their annotated locations for NP_071518.1

Status: PROVISIONAL

Source sequence(s)

X56551

UniProtKB/Swiss-Prot

Q02195

UniProtKB/TrEMBL

Q9ERN5

Conserved Domains (1) summary

smart00442
Location:63 → 191

FGF; Acidic and basic fibroblast growth factor family