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Cpxm2 carboxypeptidase X (M14 family), member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293566, updated on 5-Mar-2024

Summary

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Official Symbol
Cpxm2provided by RGD
Official Full Name
carboxypeptidase X (M14 family), member 2provided by RGD
Primary source
RGD:1310955
See related
Ensembl:ENSRNOG00000015902 AllianceGenome:RGD:1310955
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310955
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be active in extracellular space. Orthologous to human CPXM2 (carboxypeptidase X, M14 family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 131.6), Thymus (RPKM 63.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q41
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (196266930..196377350, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (186836797..186947222, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204048785..204161090, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485183 Neighboring gene G protein-coupled receptor 26 Neighboring gene ribosomal protein S27, pseudogene 7 Neighboring gene uncharacterized LOC102551752 Neighboring gene carbohydrate sulfotransferase 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Grabowski K, et al. Hypertens Res, 2022 Feb. PMID 34916661, Free PMC Article
  2. Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization. Xin X, et al. DNA Cell Biol, 1998 Oct. PMID 9809751
  3. Proteomics characterization of extracellular space components in the human aorta. Didangelos A, et al. Mol Cell Proteomics, 2010 Sep. PMID 20551380, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
    Title: Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
NOT located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inactive carboxypeptidase-like protein X2
Names
carboxypeptidase X 2 (M14 family)
carboxypeptidase X2
metallocarboxypeptidase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106306.1 → NP_001099776.1  inactive carboxypeptidase-like protein X2 precursor

    See identical proteins and their annotated locations for NP_001099776.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6HWX9, D4A536
    Related
    ENSRNOP00000042501.6, ENSRNOT00000051853.6
    Conserved Domains (4) summary
    cd03869
    Location:320 → 645
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:649 → 724
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:144 → 299
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:143 → 298
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    196266930..196377350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107648.2 → XP_038963576.1  inactive carboxypeptidase-like protein X2 isoform X1

    Conserved Domains (2) summary
    cd00057
    Location:143 → 298
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd03869
    Location:324 → 645
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

  2. XM_039107652.2 → XP_038963580.1  inactive carboxypeptidase-like protein X2 isoform X2

    Conserved Domains (3) summary
    cd11308
    Location:416 → 491
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:1 → 65
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd03869
    Location:91 → 412
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

  3. XM_063286426.1 → XP_063142496.1  inactive carboxypeptidase-like protein X2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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