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Npy1r neuropeptide Y receptor Y1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29358, updated on 6-May-2021

Summary

Official Symbol
Npy1rprovided by RGD
Official Full Name
neuropeptide Y receptor Y1provided by RGD
Primary source
RGD:3198
See related
Ensembl:ENSRNOG00000014149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NPY-1
Summary
G protein-coupled receptor for neuropeptide Y and peptide YY [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 32.2), Adrenal (RPKM 20.1) and 8 other tissues See more
Orthologs
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Genomic context

See Npy1r in Genome Data Viewer
Location:
16p14
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (23037788..23047330, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (24779480..24789131, complement)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nuclear assembly factor 1 ribonucleoprotein Neighboring gene neuropeptide Y receptor Y5 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC109393

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide Y receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables pancreatic polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pancreatic polypeptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide YY receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
NOT acts_upstream_of_or_within feeding behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within feeding behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in peristalsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuropeptide Y receptor type 1
Names
FC5
NPY1-R
Neuropepetide Y1 Receptor
neuropeptide Y1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113357.1NP_001106828.1  neuropeptide Y receptor type 1

    See identical proteins and their annotated locations for NP_001106828.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000279
    UniProtKB/TrEMBL
    G3V7T1
    Related
    ENSRNOP00000018952.4, ENSRNOT00000018952.6
    Conserved Domains (1) summary
    cd15395
    Location:40330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    23037788..23047330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253025.4XP_006253087.1  neuropeptide Y receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_006253087.1

    UniProtKB/TrEMBL
    G3V7T1
    Conserved Domains (1) summary
    cd15395
    Location:40330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_039094425.1XP_038950353.1  neuropeptide Y receptor type 1 isoform X1

    Conserved Domains (1) summary
    cd15395
    Location:40330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_006253024.4XP_006253086.1  neuropeptide Y receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_006253086.1

    UniProtKB/TrEMBL
    G3V7T1
    Conserved Domains (1) summary
    cd15395
    Location:40330
    7tmA_NPY1R; neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_039094426.1XP_038950354.1  neuropeptide Y receptor type 1 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:1343
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:188
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013032.1: Suppressed sequence

    Description
    NM_001013032.1: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript.
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