Neurog1 neurogenin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neurog1provided by RGD
Official Full Name: neurogenin 1provided by RGD
Primary source: RGD:3167
See related: Ensembl:ENSRNOG00000022405 AllianceGenome:RGD:3167
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ngn1; Neurod3
Summary: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including animal organ morphogenesis; nervous system development; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including inner ear morphogenesis; positive regulation of exit from mitosis; and regulation of neuron differentiation. Predicted to be located in perikaryon. Predicted to be active in nucleus. Orthologous to human NEUROG1 (neurogenin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (8368096..8369615)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (8362878..8364397)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9154656..9156175)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-Catenin siRNA reduces Ngnl1 and increases BMP4 mRNA expression levels in rat neural stem cells.
Title: Impact of siRNA targeting of β-catenin on differentiation of rat neural stem cells and gene expression of Ngn1 and BMP4 following in vitro hypoxic-ischemic brain damage.
Tumor necrosis factor-alpha converting enzyme (TACE) may play a role in modulating repulsive guidance molecule (RGM)-induced repulsive behavior of neurons by regulating neogenin expression on the cell surface.
Title: TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule.
Hyperbaric oxygen therapy could promote neurogenesis by beta-catenin-induced activated Ngn1 gene and repress astrocytogenesis by beta-catenin-induced down-regulated BMP-4 gene.
Title: The role of β-catenin signaling pathway on proliferation of rats neural stem cells after hyperbaric oxygen therapy in vitro.
Results identify ERK5 phosphorylation of Neurogenin 1 as a novel mechanism regulating neuronal fate commitment of cortical progenitors.
Title: ERK5 MAP kinase regulates neurogenin1 during cortical neurogenesis.
Ngn1 is required for Akt-mediated neuronal differentiation and neurite outgrowth
Title: Neurogenin 1 mediates erythropoietin enhanced differentiation of adult neural progenitor cells.
Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells.
Title: Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells.

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General gene information

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Markers

UniSTS:265421 (e-PCR)
- UniSTS:265421

Neurog1 (e-PCR), detects polymorphism
- UniSTS:265421

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in auditory behavior	ISO Inferred from Sequence Orthology more info
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in craniofacial suture morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in forebrain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in genitalia development	ISO Inferred from Sequence Orthology more info
involved_in genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hard palate morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in learned vocalization behavior	ISO Inferred from Sequence Orthology more info
involved_in mastication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of relaxation of muscle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of saliva secretion	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of muscle organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in thorax and anterior abdomen determination	ISO Inferred from Sequence Orthology more info
involved_in trigeminal nerve development	ISO Inferred from Sequence Orthology more info
involved_in vestibulocochlear nerve formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurogenin-1

Names: NGN-1; neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; neurogenic differentiation factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019207.2 → NP_062080.1 neurogenin-1

See identical proteins and their annotated locations for NP_062080.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

P70595

UniProtKB/TrEMBL

A6KAN5

Related

ENSRNOP00000015916.2, ENSRNOT00000015916.4

Conserved Domains (1) summary

cd19716
Location:83 → 154

bHLH_TS_NGN1_NeuroD3; basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins