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8 head scaffolding protein [ Salmonella phage P22 ]

Gene ID: 2944242, updated on 21-Jun-2023

Summary

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Gene symbol
8
Gene description
head scaffolding protein
Locus tag
P22gp04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella phage P22 (nat-host: Salmonella enterica subsp. enterica serovar Typhimurium)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Lederbergvirus
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Genomic context

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Sequence:
NC_002371.2 (3893..4804)

NC_002371.2Genomic Context describing neighboring genes Neighboring gene terminase small subunit Neighboring gene terminase large subunit Neighboring gene portal protein Neighboring gene head protein Neighboring gene hypothetical protein Neighboring gene head-tail adaptor Ad3 Neighboring gene head closure Hc3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002371.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular genetics of bacteriophage P22 scaffolding protein's functional domains. Weigele PR, et al. J Mol Biol, 2005 May 13. PMID 15843016
  2. Highly specific salt bridges govern bacteriophage P22 icosahedral capsid assembly: identification of the site in coat protein responsible for interaction with scaffolding protein. Cortines JR, et al. J Virol, 2014 May. PMID 24600011, Free PMC Article
  3. The energetic contributions of scaffolding and coat proteins to the assembly of bacteriophage procapsids. Zlotnick A, et al. Virology, 2012 Jun 20. PMID 22520942, Free PMC Article
  4. Decoding bacteriophage P22 assembly: identification of two charged residues in scaffolding protein responsible for coat protein interaction. Cortines JR, et al. Virology, 2011 Dec 5. PMID 21974803, Free PMC Article
  5. Bacteriophage P22 capsid size determination: roles for the coat protein telokin-like domain and the scaffolding protein amino-terminus. Suhanovsky MM, et al. Virology, 2011 Sep 1. PMID 21784500, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coat protein residue D14 is shown by cross-linking to interact with scaffolding protein residue R293 and, thus, is intimately involved in proper procapsid assembly.
    Title: Highly specific salt bridges govern bacteriophage P22 icosahedral capsid assembly: identification of the site in coat protein responsible for interaction with scaffolding protein.
  2. Scaffolding and coat proteins contributed to the assembly of bacteriophage procapsids.
    Title: The energetic contributions of scaffolding and coat proteins to the assembly of bacteriophage procapsids.
  3. Scaffolding protein residues R293 and K296 are crucial for binding to coat protein.
    Title: Decoding bacteriophage P22 assembly: identification of two charged residues in scaffolding protein responsible for coat protein interaction.
  4. Thus, a single amino acid substitution in coat protein is sufficient to change capsid size. In addition, the products of assembly of the variant coat proteins were affected by the size of the internal scaffolding protein.
    Title: Bacteriophage P22 capsid size determination: roles for the coat protein telokin-like domain and the scaffolding protein amino-terminus.
  5. Data show the scaffolding protein interacting electrostatically with the N terminus (N arm) of the coat protein through its C-terminal helix-loop-helix motif.
    Title: Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus.
  6. scaffolding protein amino acids 280 through 294 constitute its minimal coat protein binding site
    Title: Molecular genetics of bacteriophage P22 scaffolding protein's functional domains.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
head scaffolding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002371.2 Reference assembly

    Range
    3893..4804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_063736.1 head scaffolding protein [Salmonella phage P22]

    See identical proteins and their annotated locations for YP_063736.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P26748, Q7PCI6
    UniProtKB/TrEMBL
    A0A2H4A351, A0A7T8EN37, A8CGC6, Q77D92
    Conserved Domains (1) summary
    pfam09306
    Location:1 → 302
    Phage-scaffold; Bacteriophage, scaffolding protein
Nucleotide Protein
Heading Accession and Version

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