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Cenpk centromere protein K [ Rattus norvegicus (Norway rat) ]

Gene ID: 294712, updated on 13-Apr-2024

Summary

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Official Symbol
Cenpkprovided by RGD
Official Full Name
centromere protein Kprovided by RGD
Primary source
RGD:1310461
See related
Ensembl:ENSRNOG00000039740 AllianceGenome:RGD:1310461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Solt
Summary
Predicted to be involved in mitotic sister chromatid segregation. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human CENPK (centromere protein K). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 50.9), Spleen (RPKM 46.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (37094163..37155158)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (35360390..35421372)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (34312766..34373945)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene shieldin complex subunit 3 Neighboring gene tripartite motif-containing 23 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 6 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis. Yamashita A, et al. FEBS Lett, 2000 Sep 15. PMID 10996314
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in kinetochore assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centromere protein K
Names
SoxLZ/Sox6 leucine zipper binding protein in testis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399198.1 → NP_001386127.1  centromere protein K isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6I5F7
    Related
    ENSRNOP00000081169.1, ENSRNOT00000103473.1
    Conserved Domains (1) summary
    pfam11802
    Location:11 → 267
    CENP-K; Centromere-associated protein K

  2. NM_001399199.1 → NP_001386128.1  centromere protein K isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    Conserved Domains (1) summary
    pfam11802
    Location:11 → 266
    CENP-K; Centromere-associated protein K

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    37094163..37155158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760667.4 → XP_008758889.1  centromere protein K isoform X2

    Conserved Domains (1) summary
    pfam11802
    Location:11 → 216
    CENP-K; Centromere-associated protein K

  2. XM_006231889.5 → XP_006231951.1  centromere protein K isoform X1

    See identical proteins and their annotated locations for XP_006231951.1

    UniProtKB/TrEMBL
    A0A8I6G7L9, A6I5F7
    Conserved Domains (1) summary
    pfam11802
    Location:11 → 267
    CENP-K; Centromere-associated protein K

  3. XM_039101934.1 → XP_038957862.1  centromere protein K isoform X3

    Conserved Domains (1) summary
    pfam11802
    Location:1 → 164
    CENP-K; Centromere-associated protein K

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106407.1: Suppressed sequence

    Description
    NM_001106407.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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