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Mgst2 microsomal glutathione S-transferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295037, updated on 3-Apr-2024

Summary

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Official Symbol
Mgst2provided by RGD
Official Full Name
microsomal glutathione S-transferase 2provided by RGD
Primary source
RGD:1311218
See related
Ensembl:ENSRNOG00000061857 AllianceGenome:RGD:1311218
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Involved in response to lipopolysaccharide and response to organonitrogen compound. Located in cytoplasm. Orthologous to human MGST2 (microsomal glutathione S-transferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 881.8), Adrenal (RPKM 849.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q26
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (137821787..137866664)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (135679524..135715828)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (140708396..140727381)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene SET domain containing 7, histone lysine methyltransferase Neighboring gene uncharacterized LOC108350009 Neighboring gene mastermind-like transcriptional coactivator 3 Neighboring gene uncharacterized LOC134485617 Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity. Ahmad S, et al. Biochim Biophys Acta, 2015 Oct. PMID 26066610
  2. Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps. Ahmad S, et al. Biochemistry, 2013 Mar 12. PMID 23409838
  3. Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. Ma KF, et al. World J Gastroenterol, 2008 May 7. PMID 18461660, Free PMC Article
  4. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. Yang SL, et al. Pharmacology, 2007. PMID 17496435
  5. Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs. Schröder O, et al. Biochem Biophys Res Commun, 2003 Dec 12. PMID 14637132

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Liver mGST2 was up-regulated in rat model of fulminant hepatic failure.
    Title: Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene-C4 synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene-C4 synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables leukotriene-C4 synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microsomal glutathione S-transferase 2
NP_001099900.1
XP_038957936.1
XP_063137643.1
XP_063137644.1
XP_063137645.1
XP_063137646.1
XP_063137647.1
XP_063137648.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106430.1 → NP_001099900.1  microsomal glutathione S-transferase 2

    See identical proteins and their annotated locations for NP_001099900.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474003
    UniProtKB/TrEMBL
    A0A8I5ZLK2, A6JV75
    Related
    ENSRNOP00000078333.1, ENSRNOT00000100251.1
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 114
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    137821787..137866664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281578.1 → XP_063137648.1  microsomal glutathione S-transferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLK2, A6JV75

  2. XM_063281577.1 → XP_063137647.1  microsomal glutathione S-transferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLK2, A6JV75

  3. XM_063281575.1 → XP_063137645.1  microsomal glutathione S-transferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLK2, A6JV75

  4. XM_063281576.1 → XP_063137646.1  microsomal glutathione S-transferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLK2, A6JV75

  5. XM_063281573.1 → XP_063137643.1  microsomal glutathione S-transferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLK2, A6JV75

  6. XM_063281574.1 → XP_063137644.1  microsomal glutathione S-transferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLK2, A6JV75

  7. XM_039102008.2 → XP_038957936.1  microsomal glutathione S-transferase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZSH5
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 73
    MAPEG; MAPEG family
Nucleotide Protein Strain
Heading Accession and Version

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