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Ccna1 cyclin A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295052, updated on 11-Apr-2024

Summary

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Official Symbol
Ccna1provided by RGD
Official Full Name
cyclin A1provided by RGD
Primary source
RGD:1310639
See related
Ensembl:ENSRNOG00000014052 AllianceGenome:RGD:1310639
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in microtubule cytoskeleton. Predicted to be part of cyclin A1-CDK2 complex and cyclin A2-CDK2 complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 95.9), Muscle (RPKM 24.2) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccna1 in Genome Data Viewer
Location:
2q26
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141383352..141428205, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (139231738..139278066, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (144456689..144503570, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485915 Neighboring gene uncharacterized LOC134485735 Neighboring gene uncharacterized LOC134485736 Neighboring gene uncharacterized LOC134485916 Neighboring gene spartin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. 17β-Estradiol regulates cyclin A1 and cyclin B1 gene expression in adult rat seminiferous tubules. Bois C, et al. J Mol Endocrinol, 2012 Apr. PMID 22180637
  2. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. Wegiel B, et al. J Natl Cancer Inst, 2008 Jul 16. PMID 18612129, Free PMC Article
  3. Cyclin A1 expression in leukemia and normal hematopoietic cells. Yang R, et al. Blood, 1999 Mar 15. PMID 10068680
  4. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. Diederichs S, et al. Int J Cancer, 2005 Aug 20. PMID 15800920
  5. Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells. Katabami M, et al. J Biol Chem, 2005 Apr 29. PMID 15737994

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that cyclin A1 and cyclin B1 gene expression is controlled by E(2) at a concentration of 10(-9)uM only in stages IX-I of spermatogenesis.
    Title: 17β-Estradiol regulates cyclin A1 and cyclin B1 gene expression in adult rat seminiferous tubules.
  2. Oxidized low density lipoprotein induces cyclin A synthesis in a process involving ERK, JNK and NFkappaB
    Title: Oxidized low density lipoprotein induces cyclin A synthesis. Involvement of ERK, JNK and NFkappaB.
  3. analysis of expression of Cyclin D1, E, A and B1 in neurons of cerebral cortex and hippocampus
    Title: The expression of cyclins in neurons of rats after focal cerebral ischemia.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin A1-CDK2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011949.1 → NP_001011949.1  cyclin-A1

    See identical proteins and their annotated locations for NP_001011949.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079234
    UniProtKB/Swiss-Prot
    Q6AY13
    UniProtKB/TrEMBL
    A6JVE3
    Related
    ENSRNOP00000039931.3, ENSRNOT00000040002.5
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    141383352..141428205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102014.2 → XP_038957942.1  cyclin-A1 isoform X5

    Conserved Domains (2) summary
    cd20560
    Location:38 → 200
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:204 → 326
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  2. XM_063281585.1 → XP_063137655.1  cyclin-A1 isoform X4

  3. XM_017590749.3 → XP_017446238.1  cyclin-A1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY13
    UniProtKB/TrEMBL
    A6JVE3
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  4. XM_017590750.3 → XP_017446239.1  cyclin-A1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY13
    UniProtKB/TrEMBL
    A6JVE3
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  5. XM_008760987.4 → XP_008759209.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_008759209.1

    UniProtKB/Swiss-Prot
    Q6AY13
    UniProtKB/TrEMBL
    A6JVE3
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  6. XM_063281583.1 → XP_063137653.1  cyclin-A1 isoform X3

  7. XM_006232361.5 → XP_006232423.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_006232423.1

    UniProtKB/Swiss-Prot
    Q6AY13
    UniProtKB/TrEMBL
    A6JVE3
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  8. XM_063281584.1 → XP_063137654.1  cyclin-A1 isoform X4

  9. XM_063281582.1 → XP_063137652.1  cyclin-A1 isoform X3

  10. XM_063281579.1 → XP_063137649.1  cyclin-A1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLN2, A6JVE2

  11. XM_006232360.5 → XP_006232422.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_006232422.1

    UniProtKB/Swiss-Prot
    Q6AY13
    UniProtKB/TrEMBL
    A6JVE3
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  12. XM_006232359.5 → XP_006232421.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_006232421.1

    UniProtKB/Swiss-Prot
    Q6AY13
    UniProtKB/TrEMBL
    A6JVE3
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  13. XM_008760988.4 → XP_008759210.1  cyclin-A1 isoform X1

    See identical proteins and their annotated locations for XP_008759210.1

    UniProtKB/Swiss-Prot
    Q6AY13
    UniProtKB/TrEMBL
    A6JVE3
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

  14. XM_063281581.1 → XP_063137651.1  cyclin-A1 isoform X3

  15. XM_063281580.1 → XP_063137650.1  cyclin-A1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLN2, A6JVE2

  16. XM_039102011.2 → XP_038957939.1  cyclin-A1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLN2, A6JVE2
    Related
    ENSRNOP00000078779.1
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cl40454
    Location:298 → 360
    CYCLIN_SF; Cyclin box fold superfamily

  17. XM_039102012.2 → XP_038957940.1  cyclin-A1 isoform X3

    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20563
    Location:274 → 396
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
    cl40454
    Location:132 → 270
    CYCLIN_SF; Cyclin box fold superfamily

  18. XM_039102010.2 → XP_038957938.1  cyclin-A1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AY13
    UniProtKB/TrEMBL
    A6JVE3
    Conserved Domains (3) summary
    pfam16500
    Location:27 → 101
    Cyclin_N2; N-terminal region of cyclin_N
    cd20560
    Location:132 → 294
    CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
    cd20563
    Location:298 → 420
    CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY13.1 GenPept UniProtKB/Swiss-Prot:Q6AY13

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