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UL36 large tegument protein [ Suid alphaherpesvirus 1 ]

Gene ID: 2952494, updated on 18-Aug-2023

Summary

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Gene symbol
UL36
Gene description
large tegument protein
Locus tag
SuHV1_gp22
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Suid alphaherpesvirus 1 (strain: Composite of 6 strains, acronym: PRV, acronym: SuHV-1, nat-host: Sus scrofa)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:
NC_006151.1 (33056..42314, complement)

NC_006151.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase catalytic subunit Neighboring gene nuclear egress lamina protein Neighboring gene DNA packaging protein UL32 Neighboring gene DNA packaging protein UL33 Neighboring gene nuclear egress membrane protein Neighboring gene small capsid protein Neighboring gene tegument protein UL37 Neighboring gene capsid triplex subunit 1 Neighboring gene ribonucleotide reductase subunit 1 Neighboring gene ribonucleotide reductase subunit 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006151.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear egress of pseudorabies virus capsids is enhanced by a subspecies of the large tegument protein that is lost upon cytoplasmic maturation. Leelawong M, et al. J Virol, 2012 Jun. PMID 22438563, Free PMC Article
  2. A herpesvirus encoded deubiquitinase is a novel neuroinvasive determinant. Lee JI, et al. PLoS Pathog, 2009 Apr. PMID 19381253, Free PMC Article
  3. Identification of functional domains within the essential large tegument protein pUL36 of pseudorabies virus. Böttcher S, et al. J Virol, 2007 Dec. PMID 17928337, Free PMC Article
  4. Dissecting the Herpesvirus Architecture by Targeted Proteolysis. Daniel GR, et al. J Virol, 2018 Sep 1. PMID 29899099, Free PMC Article
  5. A pUL25 dimer interfaces the pseudorabies virus capsid and tegument. Liu YT, et al. J Gen Virol, 2017 Nov. PMID 29035172, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Although several regions of pUL36 are proposed to bind capsids, pUL36 was found stably anchored to the capsid exclusively at its carboxyl terminus.
    Title: Dissecting the Herpesvirus Architecture by Targeted Proteolysis.
  2. The 3D image reconstruction resolves a dimer of pUL25 forming a capsid-associated tegument complex with pUL36 and pUL17 through a coiled coil helix bundle.
    Title: A pUL25 dimer interfaces the pseudorabies virus capsid and tegument.
  3. VP1/2 promotes retrograde microtubule transport of capsids in axons.
    Title: The herpesvirus VP1/2 protein is an effector of dynein-mediated capsid transport and neuroinvasion.
  4. In this report, a conserved viral protein (VP1/2; pUL36) that directs cytoplasmic stages of egress is identified to have multiple isoforms.
    Title: Nuclear egress of pseudorabies virus capsids is enhanced by a subspecies of the large tegument protein that is lost upon cytoplasmic maturation.
  5. a conserved deubiquitinase domain embedded within a pseudorabies virus structural protein, pUL36, is essential for initial neural invasion, but is subsequently dispensable for transmission within and between neurons of the mammalian nervous system.
    Title: A herpesvirus encoded deubiquitinase is a novel neuroinvasive determinant.
  6. Thus, we identify several domains within the PrV UL36 protein, which, though not essential, are nevertheless important for virus replication.
    Title: Identification of functional domains within the essential large tegument protein pUL36 of pseudorabies virus.
  7. Virions lacking pUL11 or pUL16 incorporated less full-length pUL36 than wild-type particles, but contained increased amounts of an N-terminal fragment of pUL36 that is present only in traces in wild-type virus and the other mutants
    Title: Pseudorabies virus particles lacking tegument proteins pUL11 or pUL16 incorporate less full-length pUL36 than wild-type virus, but specifically accumulate a pUL36 N-terminal fragment.
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General gene information

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regulatory

  • Loc: c33061-33056 inference = ab initio prediction:PolyADQ: , regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
large tegument protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006151.1 Reference assembly

    Range
    33056..42314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_068339.1 large tegument protein [Suid alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_068339.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    I1WX07, Q5PPB8, Q8UZ11
    Conserved Domains (3) summary
    PHA03247
    Location:4 → 2133
    PHA03247; large tegument protein UL36; Provisional
    pfam03586
    Location:1019 → 1249
    Herpes_UL36; Herpesvirus UL36 tegument protein
    pfam04843
    Location:11 → 178
    Herpes_teg_N; Herpesvirus tegument protein, N-terminal conserved region
Nucleotide Protein
Heading Accession and Version

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