US9 membrane protein US9 [Suid alphaherpesvirus 1] - Gene

Summary

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Gene symbol: US9
Gene description: membrane protein US9
Locus tag: SuHV1_gp71
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Suid alphaherpesvirus 1 (strain: Composite of 6 strains, acronym: PRV, acronym: SuHV-1, nat-host: Sus scrofa)
Lineage: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus
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Genomic context

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Sequence:: NC_006151.1 (125231..125732)

NC_006151.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_006151.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

pUS9 is not required for fast axonal dissemination of Pseudorabies virus.
Title: Pseudorabies Virus Fast Axonal Transport Occurs by a pUS9-Independent Mechanism.
Glycoprotein M, but not glycoprotein B, was detected by Western blotting in isolated axons during Us9-null Pseudorabies virus infection.
Title: Us9-Independent Axonal Sorting and Transport of the Pseudorabies Virus Glycoprotein gM.
Pseudorabies virus glycoproteins gE/gI are required for efficient anterograde transport of viral particles in axons by mediating the interaction between Us9 and KIF1A.
Title: Glycoproteins gE and gI are required for efficient KIF1A-dependent anterograde axonal transport of alphaherpesvirus particles in neurons.
While not essential, Us9 phosphorylation enhances Us9-Kif1A-based transport of virions in axons to modulate the overall efficiency of long-distance anterograde spread of infection.
Title: Role of Us9 phosphorylation in axonal sorting and anterograde transport of pseudorabies virus.
Authors identified rat host proteins that interact with Pseudorabies virus Us9 and explored the role of KIF1A, a microtubule-dependent kinesin-3 motor involved in axonal sorting and transport.
Title: Kinesin-3 mediates axonal sorting and directional transport of alphaherpesvirus particles in neurons.
These findings show that axonal sorting of progeny viral particles is dependent upon the association of viral structures with membranes that contain functional Us9 proteins.
Title: Visualization of an alphaherpesvirus membrane protein that is essential for anterograde axonal spread of infection in neurons.
EHV-1 and BHV-1 Us9 can compensate for the loss of Pseudorabies virus (PRV) Us9, whereas VZV and HSV-1 Us9 proteins were unable to functionally replace PRV Us9.
Title: Comparison of the pseudorabies virus Us9 protein with homologs from other veterinary and human alphaherpesviruses.
Association of Us9 with lipid rafts is key for efficient targeting of structural proteins to axons and for directional spread from pre-synaptic to post-synaptic neurons and cells of the mammalian nervous system.
Title: Targeting of pseudorabies virus structural proteins to axons requires association of the viral Us9 protein with lipid rafts.
role for Us9 in viral sorting and transport
Title: Pseudorabies virus Us9 directs axonal sorting of viral capsids.

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General gene information

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Miscellaneous features

Loc: 125261-125261 transcriptional initiation site inference = ab initio prediction:NNPP:
Loc: 125726-125726 US2 experiment = approximation (+/- 10 nt) of transcriptional initation site from S1 mapping in strain NIA-3 , inference = ab initio prediction:NNPP:

polyA_site

Loc: 125732-125732 experiment = cDNA sequence in strain TNL

regulatory

Loc: 125231-125237 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box
Loc: 125697-125702 inference = ab initio prediction:PolyADQ: , regulatory_class = polyA_signal_sequence
Loc: 125697-125703 inference = ab initio prediction:TRANSFACFind: , regulatory_class = TATA_box