Pla2g1b phospholipase A2 group IB [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g1bprovided by RGD
Official Full Name: phospholipase A2 group IBprovided by RGD
Primary source: RGD:61949
See related: Ensembl:ENSRNOG00000001153 AllianceGenome:RGD:61949
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium-dependent phospholipase A2 activity and signaling receptor binding activity. Involved in fatty acid biosynthetic process; phospholipid metabolic process; and positive regulation of cell population proliferation. Located in cell surface and secretory granule. Orthologous to human PLA2G1B (phospholipase A2 group IB). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1452.5), Liver (RPKM 409.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (46802932..46814511, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (41142193..41151967, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (46879346..46890234, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, we report sPLA2-IB in rat and human brain as well as in neurons in primary culture. The distribution of sPLA2-IB seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus.
Title: Expression and induction of secretory phospholipase A2 group IB in brain.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128935 (e-PCR)
- UniSTS:212243

Pla2g1b (e-PCR), detects polymorphism
- UniSTS:546947

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bile acid binding	ISO Inferred from Sequence Orthology more info
enables bile acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
NOT involved_in arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	IEA Inferred from Electronic Annotation more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in leukotriene biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of podocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucose import	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT acts_upstream_of regulation of interleukin-1 production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase A2

Names: group IB phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B; phospholipase A2, group 1B; phospholipase A2, group IB, pancreas

NP_113773.1

EC 3.1.1.4

XP_008767444.1

EC 3.1.1.4

XP_063127301.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031585.2 → NP_113773.1 phospholipase A2 precursor

See identical proteins and their annotated locations for NP_113773.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P04055

UniProtKB/TrEMBL

A6J1T9, A6J1U0

Conserved Domains (1) summary

smart00085
Location:24 → 146

PA2c; Phospholipase A2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

46802932..46814511 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769222.4 → XP_008767444.1 phospholipase A2 isoform X2

UniProtKB/TrEMBL

A0A8L2PYZ4, A6J1U0

Related

ENSRNOP00000001525.2

Conserved Domains (1) summary

smart00085
Location:23 → 145

PA2c; Phospholipase A2
XM_063271231.1 → XP_063127301.1 phospholipase A2 isoform X1

UniProtKB/Swiss-Prot

P04055

UniProtKB/TrEMBL

A6J1T9