Myoz2 myozenin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myoz2provided by RGD
Official Full Name: myozenin 2provided by RGD
Primary source: RGD:1307669
See related: Ensembl:ENSRNOG00000014815 AllianceGenome:RGD:1307669
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable FATZ binding activity; actin binding activity; and telethonin binding activity. Predicted to be involved in several processes, including negative regulation of calcineurin-NFAT signaling cascade; sarcomere organization; and skeletal muscle fiber adaptation. Predicted to be active in Z disc and actin cytoskeleton. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 16. Orthologous to human MYOZ2 (myozenin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 4796.9) and Muscle (RPKM 1617.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (213826052..213852778, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (211141463..211168187, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (227180887..227207629, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that under weightlessness conditions, in some muscle fibers a decrease in the calsarcin--1 expression can cause intensification of the calcineurin pathway and thereby stabilize their slow phenotype
Title: Expression of calsarcin isoforms and myosin phenotype stabilization in transitional unloaded muscle.
In proteomic study of left ventricular hypertrophy, three altered protein spots corresponded to two unique proteins that were identified as Calsarcin-1 (CS-1) and ubiquinone biosynthesis protein COQ7 homolog.
Title: Proteomic analysis of early left ventricular hypertrophy secondary to hypertension: modulation by antihypertensive therapies.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI009406 (e-PCR)
- UniSTS:261757

BI280226 (e-PCR)
- UniSTS:249025

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FATZ binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables telethonin binding	IBA Inferred from Biological aspect of Ancestor more info
enables telethonin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber adaptation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myozenin-2

Names: calsarcin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399243.1 → NP_001386172.1 myozenin-2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2KAQ5, A6HVI2

Related

ENSRNOP00000075487.1, ENSRNOT00000080215.2

Conserved Domains (1) summary

pfam05556
Location:1 → 264

Calsarcin; Calcineurin-binding protein (Calsarcin)
NM_001399244.1 → NP_001386173.1 myozenin-2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

Conserved Domains (1) summary

pfam05556
Location:1 → 186

Calsarcin; Calcineurin-binding protein (Calsarcin)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

213826052..213852778 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017590785.2 → XP_017446274.1 myozenin-2 isoform X1

UniProtKB/TrEMBL

A0A8I5YBP2

Related

ENSRNOP00000076516.1, ENSRNOT00000111134.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106469.1: Suppressed sequence

Description

NM_001106469.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.