Uchl1 ubiquitin C-terminal hydrolase L1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uchl1provided by RGD
Official Full Name: ubiquitin C-terminal hydrolase L1provided by RGD
Primary source: RGD:3928
See related: Ensembl:ENSRNOG00000002343 AllianceGenome:RGD:3928
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including alpha-2A adrenergic receptor binding activity; cysteine-type peptidase activity; and ubiquitin protein ligase binding activity. Involved in sensory perception of pain and ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including neuron projection terminus; neuronal cell body; and nucleoplasm. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 1933.6), Testes (RPKM 195.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (41838859..41849743, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (41485031..41495590, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (43133224..43143942, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress.
Title: Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress.
Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats.
Title: Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats.
UCHL1-dependent autophagic flux may have a potential as an otoprotective target for the treatment of gentamycin-induced auditory cell death.
Title: Downregulated UCHL1 Accelerates Gentamicin-Induced Auditory Cell Death via Autophagy.
The increase of UCHL1 in the damaged tubules associated with high incidence of cell death.
Title: Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death?
results suggest that UCH-L1 may be associated with hippocampal mossy fiber sprouting followed the epileptogenesis through mediating phosphorylation of tau.
Title: UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model.
UCH-L1 can inhibit TNF-alpha-induced vascular smooth muscle cell migration, and this kind of effect may be partially due to its suppression role in NF-kappaB activation.
Title: Ubiquitin Carboxyl Terminal Hydrolase L1 Attenuates TNF-α-Mediated Vascular Smooth Muscle Cell Migration Through Suppression of NF-κB Activation.
investigated temporal profile of astrocytic and neuronal injury markers after TBI; different mechanisms underlie clearance of UCH-L1 and GFAP in CSF and serum
Title: Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats.
Potential of UCHL1 as biomarker for destruction of pancreatic beta cells.
Title: Potential of UCHL1 as biomarker for destruction of pancreatic beta cells.
UCH-L1 is differently processed in neurons compared with clonal cell lines and that farnesylation does not account for the membrane association in neurons.
Title: The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons.
The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis.
Title: The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Uchl1 (e-PCR), detects polymorphism
- UniSTS:516647

RH128109 (e-PCR)
- UniSTS:211417

BF399140 (e-PCR)
- UniSTS:247541

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-2A adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables omega peptidase activity	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon target recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonal transport of mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male germ cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase isozyme L1

Names: PGP 9.5; PGP9.5; UCH-L1; neuron cytoplasmic protein 9.5; ubiquitin carboxy-terminal hydrolase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin thioesterase L1

NP_058933.2

EC 3.4.19.12

XP_063129073.1

EC 3.4.19.12

XP_063129074.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017237.4 → NP_058933.2 ubiquitin carboxyl-terminal hydrolase isozyme L1

See identical proteins and their annotated locations for NP_058933.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q00981, Q6P9V8

UniProtKB/TrEMBL

A0A8L2Q0S4, A6JDB5, A6JDB6

Related

ENSRNOP00000086461.1, ENSRNOT00000094226.1

Conserved Domains (1) summary

cd09616
Location:5 → 219

Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

41838859..41849743 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273004.1 → XP_063129074.1 ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X2

UniProtKB/TrEMBL

A0A8I6G7R6
XM_063273003.1 → XP_063129073.1 ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1