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Fcgrt Fc gamma receptor and transporter [ Rattus norvegicus (Norway rat) ]

Gene ID: 29558, updated on 11-Apr-2024

Summary

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Official Symbol
Fcgrtprovided by RGD
Official Full Name
Fc gamma receptor and transporterprovided by RGD
Primary source
RGD:61811
See related
Ensembl:ENSRNOG00000020583 AllianceGenome:RGD:61811
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FcRn
Summary
Enables beta-2-microglobulin binding activity. Predicted to be involved in immune response. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human FCGRT (Fc fragment of IgG receptor and transporter). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 652.1), Spleen (RPKM 643.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104710902..104720685, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95574436..95584171, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101086872..101096159, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene proline rich and Gla domain 2 Neighboring gene nitric oxide synthase interacting protein Neighboring gene reticulocalbin 3 Neighboring gene small nucleolar RNA, C/D box 35B Neighboring gene microRNA 150 Neighboring gene ribosomal protein S11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance. Yadav SPS, et al. Am J Physiol Renal Physiol, 2021 Jan 1. PMID 33283642, Free PMC Article
  2. Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding. Thorn M, et al. Birth Defects Res B Dev Reprod Toxicol, 2012 Oct. PMID 22969064
  3. Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine. Ladinsky MS, et al. Mol Biol Cell, 2012 Jul. PMID 22573886, Free PMC Article
  4. FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. He W, et al. Nature, 2008 Sep 25. PMID 18818657, Free PMC Article
  5. Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung. Sakagami M, et al. Pharm Res, 2006 Feb. PMID 16382279

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance.
    Title: Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance.
  2. significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn
    Title: Mechanism of increased clearance of glycated albumin by proximal tubule cells.
  3. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
    Title: The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
  4. Characterization and screening of IgG binding to the neonatal Fc receptor.
    Title: Characterization and screening of IgG binding to the neonatal Fc receptor.
  5. Fetal transfer of Avastins mutated in the portion of the antibody that binds the neonatal Fc receptor (FcRn) was tested in late gestation and was found to correlate with affinities of the mutant Avastin antibody to FcRn.
    Title: Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding.
  6. The suckling rat pup intestine is a mechanistic model of FcRn-IgG-mediated transcytosis
    Title: Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice.
  7. multivesicular bodies function in IgG transport while FcRn is expressed but switch to degradative functions after weaning, when the jejunum does not express FcRn or transport IgG.
    Title: Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine.
  8. N-glycans in FcRn contribute significantly to the steady-state membrane distribution and direction of IgG transport in polarized epithelia.
    Title: N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.
  9. results present a complex picture in which Fc moves through networks of entangled tubular and irregular vesicles, only some of which are microtubule-associated, as it migrates to the basolateral surface
    Title: FcRn-mediated antibody transport across epithelial cells revealed by electron tomography.
  10. interactions between the tryptophan-based endocytosis signal, WLSL, contained within the cytoplasmic domain of the neonatal Fc receptor and the mu2 subunit of AP-2
    Title: Recognition of the tryptophan-based endocytosis signal in the neonatal Fc Receptor by the mu subunit of adaptor protein-2.
Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables IgG binding IEA
Inferred from Electronic Annotation
more info
  
enables IgG binding ISO
Inferred from Sequence Orthology
more info
  
enables IgG receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables beta-2-microglobulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-2-microglobulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables peptide antigen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in humoral immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
IgG receptor FcRn large subunit p51
Names
Fc fragment immunoglobulin G receptor
Fc fragment of IgG receptor and transporter
Fc fragment of IgG, receptor, transporter, alpha
Fc receptor, IgG, alpha chain transporter
igG Fc fragment receptor transporter alpha chain
neonatal Fc receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033351.2 → NP_203502.1  IgG receptor FcRn large subunit p51 precursor

    See identical proteins and their annotated locations for NP_203502.1

    Status: PROVISIONAL

    Source sequence(s)
    M35495
    UniProtKB/Swiss-Prot
    P13599
    UniProtKB/TrEMBL
    A0A8L2QEY2, A6JAW9
    Conserved Domains (2) summary
    pfam00129
    Location:25 → 198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cd21011
    Location:199 → 291
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104710902..104720685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229043.4 → XP_006229105.1  IgG receptor FcRn large subunit p51 isoform X1

    See identical proteins and their annotated locations for XP_006229105.1

    UniProtKB/Swiss-Prot
    P13599
    UniProtKB/TrEMBL
    A0A8L2QEY2, A6JAW9
    Related
    ENSRNOP00000093291.1
    Conserved Domains (2) summary
    pfam00129
    Location:25 → 198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cd21011
    Location:199 → 291
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains

  2. XM_039109580.1 → XP_038965508.1  IgG receptor FcRn large subunit p51 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GKP0
    Related
    ENSRNOP00000093469.1, ENSRNOT00000104770.1
    Conserved Domains (2) summary
    cd21011
    Location:110 → 199
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
    cl08246
    Location:25 → 110
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  3. XM_017589060.2 → XP_017444549.1  IgG receptor FcRn large subunit p51 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QEY2
    Conserved Domains (2) summary
    cd21011
    Location:170 → 262
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
    cl08246
    Location:1 → 169
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  4. XM_039109565.2 → XP_038965493.1  IgG receptor FcRn large subunit p51 isoform X1

    UniProtKB/Swiss-Prot
    P13599
    UniProtKB/TrEMBL
    A0A8L2QEY2, A6JAW9
    Conserved Domains (2) summary
    pfam00129
    Location:25 → 198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cd21011
    Location:199 → 291
    IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains

  5. XM_063287635.1 → XP_063143705.1  IgG receptor FcRn large subunit p51 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GKP0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13599.1 GenPept UniProtKB/Swiss-Prot:P13599

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