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Slc37a4 solute carrier family 37 member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29573, updated on 13-Apr-2024

Summary

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Official Symbol
Slc37a4provided by RGD
Official Full Name
solute carrier family 37 member 4provided by RGD
Primary source
RGD:62066
See related
Ensembl:ENSRNOG00000011361 AllianceGenome:RGD:62066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
G6pt1
Summary
Enables glucose-6-phosphate transmembrane transporter activity. Involved in several processes, including glucose-6-phosphate transport; response to glucose; and response to nutrient. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human SLC37A4 (solute carrier family 37 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 824.8), Liver (RPKM 684.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53619952..53626110)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44723216..44729301)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48716914..48723024)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene hypoxia up-regulated 1 Neighboring gene trafficking protein particle complex subunit 4 Neighboring gene ribosomal protein s25 Neighboring gene centrosomal AT-AC splicing factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evidence for glucose-6-phosphate transport in rat liver microsomes. Gerin I, et al. FEBS Lett, 2002 Apr 24. PMID 12062448
  2. Diabetes affects similarly the catalytic subunit and putative glucose-6-phosphate translocase of glucose-6-phosphatase. Li Y, et al. J Biol Chem, 1999 Nov 26. PMID 10567346
  3. Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase. Parker JC, et al. Diabetes, 1998 Oct. PMID 9753303
  4. Effects of fasting and refeeding on the activity of hepatic glucose-6-phosphatase in rats. Khan A, et al. Acta Physiol Scand, 1985 Aug. PMID 2996302
  5. Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions. Kim SY, et al. J Biol Chem, 2006 Sep 29. PMID 16891306

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. adipocytes are equipped with a functional G6PT-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system
    Title: The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system of the adipose tissue.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glucose 6-phosphate:phosphate antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose 6-phosphate:phosphate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables glucose-6-phosphate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glucose-6-phosphate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose-6-phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose-6-phosphate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glucose-6-phosphate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose-6-phosphate transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycogen metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lactate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myeloid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within respiratory burst ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucose IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glucose-6-phosphate exchanger SLC37A4
Names
glucose-6-phosphatase, transport protein 1
glucose-6-phosphate translocase
solute carrier family 37 (glucose-6-phosphate transporter), member 4
solute carrier family 37 (glycerol-6-phosphate transporter), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416484.1 → NP_001403413.1  glucose-6-phosphate exchanger SLC37A4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    Q6IRK4

  2. NM_001416485.1 → NP_001403414.1  glucose-6-phosphate exchanger SLC37A4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    Q6IRK4

  3. NM_031589.2 → NP_113777.2  glucose-6-phosphate exchanger SLC37A4

    See identical proteins and their annotated locations for NP_113777.2

    Status: PROVISIONAL

    Source sequence(s)
    BC070889
    UniProtKB/TrEMBL
    Q6IRK4, Q9Z296
    Conserved Domains (1) summary
    cd17343
    Location:10 → 417
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53619952..53626110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265025.1 → XP_063121095.1  glucose-6-phosphate exchanger SLC37A4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTY3

  2. XM_063265026.1 → XP_063121096.1  glucose-6-phosphate exchanger SLC37A4 isoform X3

    UniProtKB/TrEMBL
    F7EWB7

  3. XM_063265022.1 → XP_063121092.1  glucose-6-phosphate exchanger SLC37A4 isoform X2

  4. XM_063265021.1 → XP_063121091.1  glucose-6-phosphate exchanger SLC37A4 isoform X2

  5. XM_008766151.4 → XP_008764373.3  glucose-6-phosphate exchanger SLC37A4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTY3

  6. XM_039080967.2 → XP_038936895.2  glucose-6-phosphate exchanger SLC37A4 isoform X3

    UniProtKB/TrEMBL
    F7EWB7

  7. XM_063265020.1 → XP_063121090.1  glucose-6-phosphate exchanger SLC37A4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTY3

  8. XM_063265027.1 → XP_063121097.1  glucose-6-phosphate exchanger SLC37A4 isoform X3

    UniProtKB/TrEMBL
    F7EWB7

  9. XM_063265023.1 → XP_063121093.1  glucose-6-phosphate exchanger SLC37A4 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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