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Chst1 carbohydrate sulfotransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295934, updated on 13-Apr-2024

Summary

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Official Symbol
Chst1provided by RGD
Official Full Name
carbohydrate sulfotransferase 1provided by RGD
Primary source
RGD:1308142
See related
Ensembl:ENSRNOG00000007989 AllianceGenome:RGD:1308142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity and keratan sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process; galactose metabolic process; and keratan sulfate metabolic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in trans-Golgi network. Orthologous to human CHST1 (carbohydrate sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 104.7), Spleen (RPKM 75.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chst1 in Genome Data Viewer
Location:
3q31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (99003987..99030214)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (78552059..78574740)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (81441785..81512829)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486125 Neighboring gene uncharacterized LOC134486124 Neighboring gene uncharacterized LOC134486126 Neighboring gene uncharacterized LOC120101598 Neighboring gene uncharacterized LOC134486406 Neighboring gene uncharacterized LOC134486407

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase. Fukuta M, et al. J Biol Chem, 1997 Dec 19. PMID 9405439
  2. Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. Bistrup A, et al. J Cell Biol, 1999 May 17. PMID 10330415, Free PMC Article
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables keratan sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables keratan sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables keratan sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in keratan sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in keratan sulfate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in keratan sulfate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratan sulfate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfur compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 1
Names
GST-1
KS6ST
KSGal6ST
KSST
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1
keratan sulfate Gal-6 sulfotransferase
NP_001011955.1
XP_017447049.1
XP_017447051.1
XP_063139367.1
XP_063139368.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011955.2 → NP_001011955.1  carbohydrate sulfotransferase 1

    See identical proteins and their annotated locations for NP_001011955.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q5RJQ0
    UniProtKB/TrEMBL
    A6HNH9
    Related
    ENSRNOP00000086161.1, ENSRNOT00000114058.1
    Conserved Domains (1) summary
    pfam00685
    Location:200 → 384
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    99003987..99030214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283298.1 → XP_063139368.1  carbohydrate sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5RJQ0
    UniProtKB/TrEMBL
    A6HNH9

  2. XM_017591562.3 → XP_017447051.1  carbohydrate sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5RJQ0
    UniProtKB/TrEMBL
    A6HNH9
    Related
    ENSRNOP00000090213.1
    Conserved Domains (1) summary
    pfam00685
    Location:200 → 384
    Sulfotransfer_1; Sulfotransferase domain

  3. XM_017591560.3 → XP_017447049.1  carbohydrate sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5RJQ0
    UniProtKB/TrEMBL
    A6HNH9
    Related
    ENSRNOP00000079857.1
    Conserved Domains (1) summary
    pfam00685
    Location:200 → 384
    Sulfotransfer_1; Sulfotransferase domain

  4. XM_063283297.1 → XP_063139367.1  carbohydrate sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5RJQ0
    UniProtKB/TrEMBL
    A6HNH9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RJQ0.1 GenPept UniProtKB/Swiss-Prot:Q5RJQ0

Gene LinkOut

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