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GTF2E1 general transcription factor IIE subunit 1 [ Homo sapiens (human) ]

Gene ID: 2960, updated on 11-Apr-2024

Summary

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Official Symbol
GTF2E1provided by HGNC
Official Full Name
general transcription factor IIE subunit 1provided by HGNC
Primary source
HGNC:HGNC:4650
See related
Ensembl:ENSG00000153767 MIM:189962; AllianceGenome:HGNC:4650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FE; TF2E1; TFIIE-A
Summary
Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of transcription factor TFIID complex and transcription preinitiation complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 6.1), lymph node (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (120742744..120783069)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (123462622..123502946)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (120461591..120501916)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RAB, member of RAS oncogene family like 3 Neighboring gene MT-CO1 pseudogene 29 Neighboring gene MT-CO2 pseudogene 29 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:120461263-120461901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20339 Neighboring gene Sharpr-MPRA regulatory region 15271 Neighboring gene nucleosome assembly protein 1 like 1 pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 2049

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel zinc finger structure in the large subunit of human general transcription factor TFIIE. Okuda M, et al. J Biol Chem, 2004 Dec 3. PMID 15385556
  2. Localization of the human genes encoding the two subunits of general transcription factor TFIIE. Purrello M, et al. Genomics, 1994 Sep 1. PMID 7829083
  3. Nucleolar TFIIE plays a role in ribosomal biogenesis and performance. Phan T, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34581812, Free PMC Article
  4. MicroRNA 452 regulates GTF2E1 expression in colorectal cancer cells. Su Mo J, et al. J Genet, 2021. PMID 34553694
  5. The hRPC62 subunit of human RNA polymerase III displays helicase activity. Ayoubi LE, et al. Nucleic Acids Res, 2019 Nov 4. PMID 31529052, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nucleolar TFIIE plays a role in ribosomal biogenesis and performance.
    Title: Nucleolar TFIIE plays a role in ribosomal biogenesis and performance.
  2. MicroRNA 452 regulates GTF2E1 expression in colorectal cancer cells.
    Title: MicroRNA 452 regulates GTF2E1 expression in colorectal cancer cells.
  3. the eWH domain of hTFIIEalpha can replace the first eWH (eWH1) domain of hRPC62 in ATPase and DNA unwinding assays. Our results identify intrinsic enzymatic activities in hRPC62 and hTFIIEalpha.
    Title: The hRPC62 subunit of human RNA polymerase III displays helicase activity.
  4. The N-terminal highly acidic region of TFIIEalpha interacts with the pleckstrin homology domain of TFIIH and adopts an extended stringlike structure on the positive groove of the pleckstrin homology domain with two hydrophobic amino acids, Phe387 and Val390, inserting into two shallow hydrophobic pockets of the pleckstrin homology domain.
    Title: Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH.
  5. The N-terminal half of TFIIEalpha forms an extended winged helix (WH) domain with an additional helix, followed by a zinc-finger domain. TFIIEbeta contains the WH2 domain, followed by two coiled-coil helices intertwining with TFIIEalpha.
    Title: Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution.
  6. Association of the winged helix motif of the TFIIEalpha subunit of TFIIE with either the TFIIEbeta subunit or TFIIB distinguishes its functions in transcription.
    Title: Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription.
  7. TFIIE is an alpha/beta heterodimer in solution. A model for the quaternary architecture of the complex is proposed that provides a structural framework to discuss the function of TFIIE in the context of RNA polymerase II transcription initiation.
    Title: Structure and oligomeric state of human transcription factor TFIIE.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
  9. The specific binding of the C-terminal acidic domain (AC-D) of the human TFIIEalpha subunit to the pleckstrin homology domain (PH-D) of the human TFIIH p62 subunit is demonstrated.
    Title: Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH.
  10. interplay between TFIIEalpha and the tumor suppressor protein p53 in regulating transcriptional activation that may be modulated by the phosphorylation status of p53
    Title: p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of general transcription factor IIE, polypeptide 1, alpha 56kDa (GTF2E1; TFIIE1) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIE, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription open complex formation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIE complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
general transcription factor IIE subunit 1
Names
TFIIE alpha subunit
TFIIE-alpha
general transcription factor IIE 56 kDa subunit
general transcription factor IIE, polypeptide 1, alpha 56kDa
transcription initiation factor IIE subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005513.3 → NP_005504.2  general transcription factor IIE subunit 1

    See identical proteins and their annotated locations for NP_005504.2

    Status: VALIDATED

    Source sequence(s)
    AC117472, DA498425, S67859
    Consensus CDS
    CCDS3002.1
    UniProtKB/Swiss-Prot
    P29083, Q16103
    Related
    ENSP00000283875.5, ENST00000283875.6
    Conserved Domains (2) summary
    smart00531
    Location:28 → 175
    TFIIE; Transcription initiation factor IIE
    pfam11521
    Location:394 → 439
    TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    120742744..120783069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    123462622..123502946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29083.2 GenPept UniProtKB/Swiss-Prot:P29083

Gene LinkOut

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