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Ndufaf1 NADH:ubiquinone oxidoreductase complex assembly factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296086, updated on 5-Mar-2024

Summary

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Official Symbol
Ndufaf1provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase complex assembly factor 1provided by RGD
Primary source
RGD:1306202
See related
Ensembl:ENSRNOG00000005006 AllianceGenome:RGD:1306202
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cia30
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein complex assembly; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 11. Orthologous to human NDUFAF1 (NADH:ubiquinone oxidoreductase complex assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 139.0), Muscle (RPKM 120.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ndufaf1 in Genome Data Viewer
Location:
3q35
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127089893..127104357, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106639025..106650549, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111458227..111469239, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene OIP5 antisense RNA 1 Neighboring gene Opa interacting protein 5 Neighboring gene nucleolar and spindle associated protein 1 Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Neighboring gene inositol-trisphosphate 3-kinase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human mitochondrial complex I assembly is mediated by NDUFAF1. Vogel RO, et al. FEBS J, 2005 Oct. PMID 16218961
  2. Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Vogel RO, et al. Genes Dev, 2007 Mar 1. PMID 17344420, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complex I intermediate-associated protein 30, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
NADH dehydrogenase (ubiquinone) complex I, assembly factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106500.1 → NP_001099970.1  complex I intermediate-associated protein 30, mitochondrial

    See identical proteins and their annotated locations for NP_001099970.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    UniProtKB/TrEMBL
    A6HPG9, F1LWG4
    Related
    ENSRNOP00000006874.6, ENSRNOT00000006874.7
    Conserved Domains (1) summary
    pfam08547
    Location:126 → 299
    CIA30; Complex I intermediate-associated protein 30 (CIA30)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    127089893..127104357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234737.4 → XP_006234799.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006234799.1

    UniProtKB/TrEMBL
    A6HPG9, F1LWG4
    Conserved Domains (1) summary
    pfam08547
    Location:126 → 299
    CIA30; Complex I intermediate-associated protein 30 (CIA30)

  2. XM_006234738.5 → XP_006234800.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006234800.1

    UniProtKB/TrEMBL
    A6HPG9, F1LWG4
    Conserved Domains (1) summary
    pfam08547
    Location:126 → 299
    CIA30; Complex I intermediate-associated protein 30 (CIA30)

  3. XM_006234739.5 → XP_006234801.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006234801.1

    UniProtKB/TrEMBL
    A6HPG9, F1LWG4
    Conserved Domains (1) summary
    pfam08547
    Location:126 → 299
    CIA30; Complex I intermediate-associated protein 30 (CIA30)

  4. XM_006234740.5 → XP_006234802.1  complex I intermediate-associated protein 30, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006234802.1

    UniProtKB/TrEMBL
    A6HPG9, F1LWG4
    Conserved Domains (1) summary
    pfam08547
    Location:126 → 299
    CIA30; Complex I intermediate-associated protein 30 (CIA30)
Nucleotide Protein Strain
Heading Accession and Version

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