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Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory [ Rattus norvegicus (Norway rat) ]

Gene ID: 29640, updated on 13-Apr-2024

Summary

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Symbol
Dpm2provided by RGD
Full Name
dolichyl-phosphate mannosyltransferase subunit 2, regulatoryprovided by RGD
Primary source
RGD:2514
See related
Ensembl:ENSRNOG00000070298 AllianceGenome:RGD:2514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables dolichyl-phosphate beta-D-mannosyltransferase activity and enzyme regulator activity. Acts upstream of or within GPI anchor biosynthetic process and dolichol metabolic process. Located in perinuclear region of cytoplasm. Part of dolichol-phosphate-mannose synthase complex. Colocalizes with endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iu. Orthologous to human DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 116.0), Brain (RPKM 113.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3p11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36253548..36256592)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15855952..15858867)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11587941..11590528)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mitochondrial import inner membrane translocase subunit Tim17-B-like Neighboring gene uncharacterized LOC134486072 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. Maeda Y, et al. EMBO J, 2000 Jun 1. PMID 10835346, Free PMC Article
  2. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. Maeda Y, et al. EMBO J, 1998 Sep 1. PMID 9724629, Free PMC Article
  3. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
  4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dolichyl-phosphate beta-D-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within dolichol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dolichol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of dolichol-phosphate-mannose synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dolichol-phosphate-mannose synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of dolichol-phosphate-mannose synthase complex IEA
Inferred from Electronic Annotation
more info
  
part_of dolichol-phosphate-mannose synthase complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IEA
Inferred from Electronic Annotation
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dolichol phosphate-mannose biosynthesis regulatory protein
Names
DPM synthase subunit 2
dolichol-phosphate (beta-D) mannosyltransferase 2
dolichol-phosphate mannose synthase subunit 2
dolichol-phosphate mannosyltransferase 2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
NP_062125.1
XP_063139484.1
XP_063139485.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019252.2 → NP_062125.1  dolichol phosphate-mannose biosynthesis regulatory protein

    See identical proteins and their annotated locations for NP_062125.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q9Z325
    UniProtKB/TrEMBL
    A0A8I6AHS9
    Related
    ENSRNOP00000092836.1, ENSRNOT00000109105.1
    Conserved Domains (1) summary
    pfam07297
    Location:5 → 78
    DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    36253548..36256592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283414.1 → XP_063139484.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform X1

  2. XM_063283415.1 → XP_063139485.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z325.3 GenPept UniProtKB/Swiss-Prot:Q9Z325

Gene LinkOut

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