Itgav integrin subunit alpha V [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itgavprovided by RGD
Official Full Name: integrin subunit alpha Vprovided by RGD
Primary source: RGD:1310613
See related: Ensembl:ENSRNOG00000004912 AllianceGenome:RGD:1310613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd51
Summary: Enables signaling receptor binding activity. Involved in several processes, including blood vessel morphogenesis; positive regulation of cell population proliferation; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in several cellular components, including cell projection membrane; external side of plasma membrane; and focal adhesion. Predicted to be part of alphav-beta3 integrin-HMGB1 complex; alphav-beta3 integrin-IGF-1-IGF1R complex; and integrin complex. Used to study corneal neovascularization; coronary stenosis; and ischemia. Biomarker of hypertension. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 315.8), Adrenal (RPKM 247.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (89245382..89333512)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (68838514..68926653)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (71113269..71205958)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin alphavbeta5 which induces LSECs dysfunction, promoting hepatic sinusoidal capillarization regulates VN expression via ERK/FAK pathway under high glucose/ox-LDL
Title: High glucose/ox-LDL induced hepatic sinusoidal capillarization via αvβ5/FAK/ERK signaling pathway.
the effects on cardiac fibroblasts , isolated by spontaneously hypertensive rats (SHR), of integrin alphanubeta5 inhibition in myofibroblast differentiation.
Title: Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats.
findings demonstrate that, in SI-treated rats, oxidative stress activates STAT3 signaling which up-regulates miR-25 expression, in a very early stage. The increased miR-25 then inhibits ITGAV and PEDF expressions, resulting in RPE phagocytosis dysfunction and then RPE apoptosis and visual impairment as observed in patients with AMD.
Title: miR-25 Mediates Retinal Degeneration Via Inhibiting ITGAV and PEDF in Rat.
These findings uncover a hitherto unrecognized role for hemichannels in the regulation of astrocyte migration via P2X7R transactivation induced by integrin-mediated ATP release.
Title: Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration.
The membrane fraction of diabetic-derived fibroblasts showed a decrease of integrin subunits alpha5 and alphav, which was confirmed by immunocytochemistry assays.
Title: Hyperglycemia reduces integrin subunits alpha v and alpha 5 on the surface of dermal fibroblasts contributing to deficient migration.
These data support the hypothesis that IL-1beta was initially induced by hyperoxia; alphavbeta6 subsequently interacted with and activated TGF-beta1.
Title: Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation.
Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit.
Title: Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis.
When administered after establishment of early pathophysiologic changes in renal function, the anti-integrin alphaVbeta3 antibody reversed the effects of diabetes normalizing albuminuria and profibrotic proteins in the kidney.
Title: Blocking αVβ3 integrin ligand occupancy inhibits the progression of albuminuria in diabetic rats.
These results demonstrate that alphav beta3 integrin-mediated angiogenesis is critical for recovering fracture resistance after bone injury.
Title: Antagonizing the αv β3 integrin inhibits angiogenesis and impairs woven but not lamellar bone formation induced by mechanical loading.
both alphanu and beta1 integrins interfered with Abeta-induced neurotoxicity in hippocampal neurons and that this mechanism partially contributes to the activation of the Integrin-FAK signaling pathway.
Title: αν and β1 Integrins mediate Aβ-induced neurotoxicity in hippocampal neurons via the FAK signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Got143 (e-PCR)
- UniSTS:112413

RH140315 (e-PCR)
- UniSTS:222392

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix protein binding	ISO Inferred from Sequence Orthology more info
contributes_to fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
contributes_to insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
contributes_to neuregulin binding	ISO Inferred from Sequence Orthology more info
contributes_to opsonin binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in apolipoprotein A-I-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of entry of bacterium into host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to nitric oxide	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta production	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of alphav-beta3 integrin-HMGB1 complex	ISO Inferred from Sequence Orthology more info
part_of alphav-beta3 integrin-IGF-1-IGF1R complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta3 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta5 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta6 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta8 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-V

Names: Dnmt3l-ps1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398692.1 → NP_001385621.1 integrin alpha-V isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

Related

ENSRNOP00000069681.2, ENSRNOT00000088549.2

Conserved Domains (4) summary

smart00191
Location:367 → 421

Int_alpha; Integrin alpha (beta-propellor repeats)

sd00039
Location:126 → 183

7WD40; WD40 repeat [structural motif]

pfam08441
Location:467 → 909

Integrin_alpha2; Integrin alpha

pfam13517
Location:221 → 271

VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
NM_001398693.1 → NP_001385622.1 integrin alpha-V isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

F1LZX9

Related

ENSRNOP00000006961.8, ENSRNOT00000006961.8

Conserved Domains (4) summary

smart00191
Location:366 → 420

Int_alpha; Integrin alpha (beta-propellor repeats)

sd00039
Location:51 → 119

7WD40; WD40 repeat [structural motif]

pfam08441
Location:466 → 908

Integrin_alpha2; Integrin alpha

pfam13517
Location:220 → 270

VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

89245382..89333512

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283421.1 → XP_063139491.1 integrin alpha-V isoform X1
XM_039106447.1 → XP_038962375.1 integrin alpha-V isoform X2

Conserved Domains (4) summary

smart00191
Location:185 → 239

Int_alpha; Integrin alpha (beta-propellor repeats)

sd00039
Location:72 → 116

7WD40; WD40 repeat [structural motif]

pfam08441
Location:285 → 727

Integrin_alpha2; Integrin alpha

pfam13517
Location:39 → 89

VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

RNA

XR_010064599.1 RNA Sequence
XR_010064598.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106549.1: Suppressed sequence

Description

NM_001106549.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: ITGAV (GeneID:396420).