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Helz2 helicase with zinc finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296474, updated on 13-Apr-2024

Summary

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Official Symbol
Helz2provided by RGD
Official Full Name
helicase with zinc finger 2provided by RGD
Primary source
RGD:1306056
See related
Ensembl:ENSRNOG00000013267 AllianceGenome:RGD:1306056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pric285; RGD1306056
Summary
Predicted to enable 5'-3' DNA helicase activity and nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human HELZ2 (helicase with zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 130.8), Spleen (RPKM 126.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q43
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188716370..188730776, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168338813..168353219, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176730024..176744382, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350541 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene fibronectin type III domain containing 11 Neighboring gene uncharacterized LOC120101833 Neighboring gene glucocorticoid modulatory element binding protein 2 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene stathmin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. Tomaru T, et al. Endocrinology, 2006 Jan. PMID 16239304
  2. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, et al. Proc Natl Acad Sci U S A, 2002 Sep 3. PMID 12189208, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. characterization of Pric285 as a coactivator and as a transcriptionally active peroxisome proliferator-activated receptor alpha-interacting cofactor complex in rat liver.
    Title: Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables exoribonuclease II activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3'-5' exoribonuclease HELZ2
Names
helicase with zinc finger 2, transcriptional coactivator
helicase with zinc finger domain 2
peroxisomal proliferator-activated receptor A interacting complex 285
peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein
NP_001292205.1
XP_038960623.1
XP_063139513.1
XP_063139514.1
XP_063139515.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305276.1 → NP_001292205.1  3'-5' exoribonuclease HELZ2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZPT9, A0A8I6AGQ7
    Related
    ENSRNOP00000080222.1, ENSRNOT00000113133.1
    Conserved Domains (4) summary
    smart00955
    Location:1565 → 1923
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18040
    Location:2446 → 2721
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    pfam13087
    Location:2701 → 2906
    AAA_12; AAA domain
    cl28899
    Location:759 → 989
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    188716370..188730776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104695.2 → XP_038960623.1  3'-5' exoribonuclease HELZ2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZPT9, A0A8I6AGQ7
    Conserved Domains (4) summary
    smart00955
    Location:1565 → 1923
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18040
    Location:2446 → 2721
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    pfam13087
    Location:2701 → 2906
    AAA_12; AAA domain
    cl28899
    Location:759 → 989
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  2. XM_063283444.1 → XP_063139514.1  3'-5' exoribonuclease HELZ2 isoform X3

  3. XM_063283443.1 → XP_063139513.1  3'-5' exoribonuclease HELZ2 isoform X2

  4. XM_063283445.1 → XP_063139515.1  3'-5' exoribonuclease HELZ2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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