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Spaca9 sperm acrosome associated 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296610, updated on 13-Apr-2024

Summary

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Official Symbol
Spaca9provided by RGD
Official Full Name
sperm acrosome associated 9provided by RGD
Primary source
RGD:727909
See related
Ensembl:ENSRNOG00000012697 AllianceGenome:RGD:727909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rsb66
Summary
Predicted to enable calcium-dependent protein binding activity. Located in cytoplasm and nucleus. Orthologous to human SPACA9 (sperm acrosome associated 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 110.9) and Lung (RPKM 20.6) See more
Orthologs
human mouse all
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Genomic context

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See Spaca9 in Genome Data Viewer
Location:
3p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (32417350..32426776, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (12019376..12028801, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7269851..7279253, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene growth factor independent 1B transcriptional repressor Neighboring gene TSC complex subunit 1 Neighboring gene adenylate kinase 8 Neighboring gene RNA, U1 small nuclear 136

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). Chen X, et al. Biochem Cell Biol, 2008 Aug. PMID 18756329
  2. A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome. Bhattacharya R, et al. BMC Cell Biol, 2013 Nov 20. PMID 24256100, Free PMC Article
  3. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
  4. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  5. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC114240

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axoneme assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary base IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ciliary base ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sperm acrosome-associated protein 9
Names
Rsb-66 protein
uncharacterized protein C9orf9 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401818.1 → NP_001388747.1  sperm acrosome-associated protein 9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6A8T2
    Related
    ENSRNOP00000088937.1, ENSRNOT00000120222.1
    Conserved Domains (1) summary
    pfam15120
    Location:2 → 165
    SPACA9; Sperm acrosome-associated protein 9

  2. NM_181694.3 → NP_859045.2  sperm acrosome-associated protein 9 isoform 2

    See identical proteins and their annotated locations for NP_859045.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q4V8P4, Q7TSB9
    Conserved Domains (1) summary
    pfam15120
    Location:2 → 165
    SPACA9; Sperm acrosome-associated protein 9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    32417350..32426776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233766.4 → XP_006233828.1  sperm acrosome-associated protein 9 isoform X3

    See identical proteins and their annotated locations for XP_006233828.1

    UniProtKB/TrEMBL
    A0A8L2Q9C4, A6JTP7
    Related
    ENSRNOP00000017004.3
    Conserved Domains (1) summary
    pfam15120
    Location:43 → 205
    DUF4561; Domain of unknown function (DUF4561)

  2. XM_063283481.1 → XP_063139551.1  sperm acrosome-associated protein 9 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GL53

  3. XM_063283482.1 → XP_063139552.1  sperm acrosome-associated protein 9 isoform X4

    UniProtKB/Swiss-Prot
    Q4V8P4, Q7TSB9

  4. XM_017591644.3 → XP_017447133.1  sperm acrosome-associated protein 9 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A8T2
    Conserved Domains (1) summary
    pfam15120
    Location:2 → 165
    SPACA9; Sperm acrosome-associated protein 9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V8P4.1 GenPept UniProtKB/Swiss-Prot:Q4V8P4

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