C1qb complement C1q B chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1qbprovided by RGD
Official Full Name: complement C1q B chainprovided by RGD
Primary source: RGD:2229
See related: Ensembl:ENSRNOG00000012749 AllianceGenome:RGD:2229
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Adia
Summary: Predicted to enable identical protein binding activity. Involved in aging; brain development; and response to glucocorticoid. Located in synapse. Part of complement component C1 complex. Biomarker of ocular hypertension. Orthologous to human C1QB (complement C1q B chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1372.5), Thymus (RPKM 334.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (154402276..154407827, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (149118843..149124394, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (155246444..155251995, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in the pancreatic islet immune microenvironment in type 1 diabetes mellitus.
Title: Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in the pancreatic islet immune microenvironment in type 1 diabetes mellitus.
Data suggest that complement C1q expression may play a principal role in hepatic ischemia-reperfusion (I/R) injury, particularly at the early stage of perfusion.
Title: Effect of complement C1q expression on hepatic ischemia-reperfusion injury in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in inner ear development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in synapse pruning	IEA Inferred from Electronic Annotation more info
involved_in synapse pruning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
part_of complement component C1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of complement component C1q complex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q subcomponent subunit B

Names: adiponectin a; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019262.2 → NP_062135.2 complement C1q subcomponent subunit B precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005, X71127

UniProtKB/Swiss-Prot

P31721

UniProtKB/TrEMBL

A6ITC3, G3V7N9

Related

ENSRNOP00000017060.3, ENSRNOT00000017060.7

Conserved Domains (2) summary

pfam01391
Location:31 → 64

Collagen; Collagen triple helix repeat (20 copies)

cl23878
Location:113 → 250

C1q; C1q domain