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Tnpo3 transportin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296954, updated on 5-Mar-2024

Summary

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Official Symbol
Tnpo3provided by RGD
Official Full Name
transportin 3provided by RGD
Primary source
RGD:1308938
See related
Ensembl:ENSRNOG00000021758 AllianceGenome:RGD:1308938
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in annulate lamellae and nuclear envelope. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 174.3), Thymus (RPKM 171.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q22
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59108278..59197012, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58142954..58220365, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56820023..56897310, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene kielin cysteine rich BMP regulator Neighboring gene interferon regulatory factor 5 Neighboring gene uncharacterized LOC134486568 Neighboring gene uncharacterized LOC102552812 Neighboring gene uncharacterized LOC134486745

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel mutation in TNPO3 causes congenital limb-girdle myopathy with slow progression. Vihola A, et al. Neurol Genet, 2019 Jun. PMID 31192305, Free PMC Article
  2. The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection. Rodríguez-Mora S, et al. PLoS Pathog, 2019 Aug. PMID 31465518, Free PMC Article
  3. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Jang S, et al. Nucleic Acids Res, 2019 May 21. PMID 30916345, Free PMC Article
  4. Structural basis for nuclear import of splicing factors by human Transportin 3. Maertens GN, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24449914, Free PMC Article
  5. Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase. Taltynov O, et al. J Biol Chem, 2013 Aug 30. PMID 23878195, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in annulate lamellae ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transportin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106587.1 → NP_001100057.1  transportin-3

    See identical proteins and their annotated locations for NP_001100057.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/TrEMBL
    A0A8I6G251, A6IEE3
    Related
    ENSRNOP00000078660.1, ENSRNOT00000113944.1
    Conserved Domains (2) summary
    smart00913
    Location:33 → 96
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:121 → 248
    Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    59108278..59197012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285739.1 → XP_063141809.1  transportin-3 isoform X1

  2. XM_006236186.5 → XP_006236248.1  transportin-3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6G251
    Conserved Domains (1) summary
    pfam08389
    Location:55 → 182
    Xpo1; Exportin 1-like protein

  3. XM_039107279.2 → XP_038963207.1  transportin-3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G251
    Conserved Domains (2) summary
    smart00913
    Location:33 → 96
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:121 → 248
    Xpo1; Exportin 1-like protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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