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Bpgm bisphosphoglycerate mutase [ Rattus norvegicus (Norway rat) ]

Gene ID: 296973, updated on 3-Apr-2024

Summary

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Official Symbol
Bpgmprovided by RGD
Official Full Name
bisphosphoglycerate mutaseprovided by RGD
Primary source
RGD:735018
See related
Ensembl:ENSRNOG00000010133 AllianceGenome:RGD:735018
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab2-098
Summary
Predicted to enable bisphosphoglycerate mutase activity; hydrolase activity; and phosphoglycerate mutase activity. Involved in erythrocyte development. Human ortholog(s) of this gene implicated in familial erythrocytosis 8. Orthologous to human BPGM (bisphosphoglycerate mutase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 880.3), Muscle (RPKM 473.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64106809..64135749)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63139730..63168581)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (61912210..61940697)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 6, pseudogene 4 Neighboring gene aldo-keto reductase family 1, member B7 Neighboring gene caldesmon 1 Neighboring gene uncharacterized LOC120102254 Neighboring gene AGBL carboxypeptidase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Changes in enzyme activities involved in the degradation of 1,3-bisphosphoglycerate during erythropoiesis in rat bone marrow. Pineda M, et al. Cell Biochem Funct, 1984 Oct. PMID 6097373
  2. Compound heterozygosity in a complete erythrocyte bisphosphoglycerate mutase deficiency. Lemarchandel V, et al. Blood, 1992 Nov 15. PMID 1421379
  3. Isolation, characterization, and structure of a mutant 89 Arg----Cys bisphosphoglycerate mutase. Implication of the active site in the mutation. Rosa R, et al. J Biol Chem, 1989 May 15. PMID 2542247
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables bisphosphoglycerate mutase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to protozoan ISO
Inferred from Sequence Orthology
more info
  
involved_in erythrocyte development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within erythrocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolytic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleoside phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oxygen transport ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bisphosphoglycerate mutase
Names
2,3-bisphosphoglycerate mutase
NP_955414.1
XP_006236321.1
XP_038963221.1
XP_063141817.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199382.2 → NP_955414.1  bisphosphoglycerate mutase

    See identical proteins and their annotated locations for NP_955414.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    F7F6N0, Q6P6G4
    Related
    ENSRNOP00000013566.4, ENSRNOT00000013569.5
    Conserved Domains (1) summary
    cl11399
    Location:4 → 253
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    64106809..64135749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107293.2 → XP_038963221.1  bisphosphoglycerate mutase isoform X1

    UniProtKB/TrEMBL
    F7F6N0, Q6P6G4
    Conserved Domains (1) summary
    cl11399
    Location:4 → 253
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  2. XM_063285747.1 → XP_063141817.1  bisphosphoglycerate mutase isoform X1

    UniProtKB/TrEMBL
    F7F6N0, Q6P6G4

  3. XM_006236259.5 → XP_006236321.1  bisphosphoglycerate mutase isoform X1

    See identical proteins and their annotated locations for XP_006236321.1

    UniProtKB/TrEMBL
    F7F6N0, Q6P6G4
    Conserved Domains (1) summary
    cl11399
    Location:4 → 253
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein Strain
Heading Accession and Version

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