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Tmem176a transmembrane protein 176A [ Rattus norvegicus (Norway rat) ]

Gene ID: 297077, updated on 3-Apr-2024

Summary

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Official Symbol
Tmem176aprovided by RGD
Official Full Name
transmembrane protein 176Aprovided by RGD
Primary source
RGD:1310725
See related
Ensembl:ENSRNOG00000023708 AllianceGenome:RGD:1310725
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310725; 0610011i04rik
Summary
Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be integral component of membrane. Orthologous to human TMEM176A (transmembrane protein 176A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 543.8), Spleen (RPKM 456.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (79101946..79109499)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77774940..77778620)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78458735..78462415)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 1 Neighboring gene GTPase, IMAP family member 5 Neighboring gene transmembrane protein 176B Neighboring gene amine oxidase, copper containing 1 Neighboring gene DAB2 interacting protein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tmem176B and Tmem176A are associated with the immature state of dendritic cells. Condamine T, et al. J Leukoc Biol, 2010 Sep. PMID 20501748
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC112703

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 176A
Names
hepatocellular carcinoma-associated antigen 112

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039008.1 → NP_001034097.1  transmembrane protein 176A

    See identical proteins and their annotated locations for NP_001034097.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098714
    UniProtKB/Swiss-Prot
    Q4G068
    UniProtKB/TrEMBL
    A6K0J1
    Related
    ENSRNOP00000048649.2, ENSRNOT00000049891.5
    Conserved Domains (1) summary
    pfam04103
    Location:63 → 223
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    79101946..79109499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285768.1 → XP_063141838.1  transmembrane protein 176A isoform X1

  2. XM_063285769.1 → XP_063141839.1  transmembrane protein 176A isoform X2

    UniProtKB/Swiss-Prot
    Q4G068
    UniProtKB/TrEMBL
    A6K0J1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G068.1 GenPept UniProtKB/Swiss-Prot:Q4G068

Gene LinkOut

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