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Rnf181 ring finger protein 181 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297337, updated on 3-Apr-2024

Summary

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Official Symbol
Rnf181provided by RGD
Official Full Name
ring finger protein 181provided by RGD
Primary source
RGD:1359698
See related
Ensembl:ENSRNOG00000012035 AllianceGenome:RGD:1359698
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein autoubiquitination. Predicted to be active in cytoplasm. Orthologous to human RNF181 (ring finger protein 181). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 390.7), Testes (RPKM 275.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105972778..105979624, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104414586..104421433, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100222087..100228809, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene surfactant protein B Neighboring gene ubiquitin specific peptidase 39 Neighboring gene similar to human chromosome 2 open reading frame 68 Neighboring gene transmembrane protein 150A Neighboring gene vesicle-associated membrane protein 5 Neighboring gene uncharacterized LOC134486592 Neighboring gene vesicle-associated membrane protein 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181. Pedersen SM, et al. Mol Cell Biol, 2015 Dec 28. PMID 26711259, Free PMC Article
  2. Protein microarray characterization of the S-nitrosoproteome. Lee YI, et al. Mol Cell Proteomics, 2014 Jan. PMID 24105792, Free PMC Article
  3. Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2. Fernandez-Caggiano M, et al. J Biol Chem, 2016 May 6. PMID 26945066, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94464

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF181
Names
RING-type E3 ubiquitin transferase RNF181
NP_001007648.1
XP_038963245.1
XP_038963247.1
XP_063141849.1
XP_063141850.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007647.1 → NP_001007648.1  E3 ubiquitin-protein ligase RNF181

    See identical proteins and their annotated locations for NP_001007648.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079313
    UniProtKB/Swiss-Prot
    Q6AXU4
    UniProtKB/TrEMBL
    A6IAB1, A6IAB2
    Related
    ENSRNOP00000016699.3, ENSRNOT00000016699.7
    Conserved Domains (1) summary
    cd16669
    Location:87 → 132
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    105972778..105979624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107317.1 → XP_038963245.1  E3 ubiquitin-protein ligase RNF181 isoform X2

    Conserved Domains (1) summary
    cd16669
    Location:55 → 100
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

  2. XM_039107319.2 → XP_038963247.1  E3 ubiquitin-protein ligase RNF181 isoform X3

    UniProtKB/TrEMBL
    A6IAB3
    Conserved Domains (1) summary
    cd16669
    Location:40 → 85
    RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

  3. XM_063285779.1 → XP_063141849.1  E3 ubiquitin-protein ligase RNF181 isoform X1

    UniProtKB/Swiss-Prot
    Q6AXU4
    UniProtKB/TrEMBL
    A6IAB2

  4. XM_063285780.1 → XP_063141850.1  E3 ubiquitin-protein ligase RNF181 isoform X3

    UniProtKB/TrEMBL
    A6IAB3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXU4.1 GenPept UniProtKB/Swiss-Prot:Q6AXU4

Gene LinkOut

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