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Capg capping actin protein, gelsolin like [ Rattus norvegicus (Norway rat) ]

Gene ID: 297339, updated on 3-Apr-2024

Summary

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Official Symbol
Capgprovided by RGD
Official Full Name
capping actin protein, gelsolin likeprovided by RGD
Primary source
RGD:1311724
See related
Ensembl:ENSRNOG00000013668 AllianceGenome:RGD:1311724
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in several cellular components, including Flemming body; microtubule cytoskeleton; and nuclear lumen. Predicted to be active in actin cytoskeleton; cytoplasm; and extracellular space. Orthologous to human CAPG (capping actin protein, gelsolin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 175.4), Lung (RPKM 112.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (106152912..106170010)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104594743..104611856)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100395693..100419447)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene SH2 domain containing 6 Neighboring gene transfer RNA proline (anticodon AGG) 74 Neighboring gene ELMO domain containing 3 Neighboring gene retinol saturase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The F-actin filament capping protein CapG is a bona fide nucleolar protein. Hubert T, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18938132
  2. Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing. Witke W, et al. J Cell Biol, 2001 Aug 20. PMID 11514591, Free PMC Article
  3. The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Hubert T, et al. Biochem Biophys Res Commun, 2009 Feb 27. PMID 19166812
  4. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. Van Impe K, et al. Traffic, 2008 May. PMID 18266911
  5. L-plastin nanobodies perturb matrix degradation, podosome formation, stability and lifetime in THP-1 macrophages. De Clercq S, et al. PLoS One, 2013. PMID 24236012, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell projection assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
macrophage-capping protein
Names
actin regulatory protein CAP-G
capping protein (actin filament), gelsolin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013086.1 → NP_001013104.1  macrophage-capping protein

    See identical proteins and their annotated locations for NP_001013104.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079104
    UniProtKB/Swiss-Prot
    Q6AYC4
    UniProtKB/TrEMBL
    A0A8I6A6Z2, A6IAC6
    Related
    ENSRNOP00000087979.1, ENSRNOT00000108841.1
    Conserved Domains (3) summary
    cd11289
    Location:139 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    106152912..106170010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236661.5 → XP_006236723.1  macrophage-capping protein isoform X2

    See identical proteins and their annotated locations for XP_006236723.1

    UniProtKB/Swiss-Prot
    Q6AYC4
    UniProtKB/TrEMBL
    A0A8I6A6Z2, A6IAC6
    Conserved Domains (3) summary
    cd11289
    Location:139 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  2. XM_006236663.5 → XP_006236725.1  macrophage-capping protein isoform X2

    See identical proteins and their annotated locations for XP_006236725.1

    UniProtKB/Swiss-Prot
    Q6AYC4
    UniProtKB/TrEMBL
    A0A8I6A6Z2, A6IAC6
    Conserved Domains (3) summary
    cd11289
    Location:139 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  3. XM_039107321.2 → XP_038963249.1  macrophage-capping protein isoform X2

    UniProtKB/Swiss-Prot
    Q6AYC4
    UniProtKB/TrEMBL
    A0A8I6A6Z2, A6IAC6
    Conserved Domains (3) summary
    cd11289
    Location:139 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  4. XM_039107320.2 → XP_038963248.2  macrophage-capping protein isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q9I9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYC4.1 GenPept UniProtKB/Swiss-Prot:Q6AYC4

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